An efficient copper-catalyzed coupling of aryl halides with imidazoles
An efficient copper-catalyzed coupling of aryl halides with imidazoles
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DOI：
10.1016/s0040-4039(99)00291-9
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发表时间：
1999-04-02
影响因子：
1.8
通讯作者：
Buchwald, SL
中科院分区：
文献类型：
--
作者：
Kiyomori, A;Marcoux, JF;Buchwald, SL
铜催化的咪唑N-芳基化反应可以用(CuOTf)(2)完成。在110-125℃的温度下，以苯为铜源，以CS2CO3为碱，在二甲苯中加入L、邻菲咯啉(Phen)和反式，反式二亚甲基丙酮(Dba)是工艺成功的关键。高产率分离得到N-芳基咪唑类化合物。(C)1999爱思唯尔科学有限公司。保留所有权利。
Copper-catalyzed N-arylation of imidazoles can be accomplished using (CuOTf)(2). benzene as a copper source and Cs2CO3 as a base in xylenes at 110-125 degrees C. Addition of l,l0-phenanthroline (phen) and trans, trans-dibenzylideneacetone (dba) was crucial to the success of the process. The products, N-arylimidazoles, were isolated in high yields. (C) 1999 Elsevier Science Ltd. All rights reserved.