Expression of the mouse Delta1 gene during organogenesis and fetal development
Expression of the mouse Delta1 gene during organogenesis and fetal development
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DOI：
10.1016/s0925-4773(99)00065-9
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发表时间：
1999-06-01
影响因子：
2.6
通讯作者：
Gossler, A
中科院分区：
文献类型：
--
作者：
Beckers, J;Clark, A;Gossler, A
由进化上保守的Notch信号通路介导的细胞间通讯在多种生物的不同组织中调节细胞命运决定和模式形成（Artavanis - Tsakonas等人，1995年，《科学》268卷，225 - 232页）。相邻细胞之间的信号转导是通过DSL和Notch蛋白的结合来实现的，它们分别作为配体（DSL）和受体（Notch）相互作用。小鼠Delta 1（类Delta 1；Dll1）编码四种已知的哺乳动物DSL蛋白之一，对正常的体节发生和神经元分化至关重要。在此，我们利用从靶向的Delta1:lacZ敲入等位基因（Dll1(lacZ)）表达的lacZ基因产物的高灵敏度组织化学检测，描述了器官发生和胎儿发育过程中Delta1的表达。我们发现Delta1在几个器官的上皮导管、骨骼肌和平滑肌、中枢神经系统以及一些感觉上皮中表达。（C）1999年爱尔兰爱思唯尔科学有限公司。保留所有权利。
Cell-to-cell communication mediated by the evolutionary conserved Notch signalling pathway regulates cell fate decisions and patterning in various tissues in diverse organisms (Artavanis-Tsakonas et al., 1995, Science 268, 225-232). Signalling between neighboring cells is transduced by binding of DSL and Notch proteins which interact as ligand (DSL) and receptor (Notch). Mouse Delta 1 (delta-like 1; Dll1) encodes one of the four known mammalian DSL proteins and is essential for normal somitogenesis and neuronal differentiation. Here, we describe Delta1 expression during organogenesis and fetal development using the highly sensitive histochemical detection of the lacZ gene product expressed from a targeted Delta1:lacZ knock-in allele (Dll1(lacZ)). We find that Delta1 is expressed in epithelial ducts of several organs, skeletal and smooth muscles, the central nervous system, as well as some sensory epithelia. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.