Potent effects of low levels of MHC class II-associated invariant chain on CD4+ T cell development.
Potent effects of low levels of MHC class II-associated invariant chain on CD4+ T cell development.
复制标题
低水平的 MHC II 类相关不变链对 CD4 T 细胞发育的有效影响。
DOI：
10.1016/1074-7613(95)90120-5
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发表时间：
1995
期刊：
影响因子：
32.4
通讯作者：
Miller,J
中科院分区：
文献类型：
--
作者：
Naujokas,MF;Arneson,LS;Fineschi,B;Peterson,ME;Sitterding,S;Hammond,AT;Reilly,C;Lo,D;Miller,J
不变链（li）阴性小鼠表现出MHC II类组装和转运缺陷，导致表面II类水平降低、抗原呈递改变和CD4+T细胞的阳性选择无效。在li阴性小鼠中成熟的许多CD4+T细胞表达与异常阳性选择或外周活化一致的细胞表面表型。用低水平的p31或p41形式的Ii重建这些小鼠不能恢复大量II类或II类表面表达的转运，但令人惊讶地恢复了通过CD4+T细胞的数量和表面表型测量的阳性选择。因此，一个锂依赖性的过程，独立于对II类表面密度的影响，似乎是需要正常的CD4+T细胞的阳性选择。
Invariant chain (li)-negative mice exhibit defects in MHC class II assembly and transport that results in reduced levels of surface class II, altered antigen presentation, and inefficient positive selection of CD4+T cells. Many CD4+T cells that do mature in li-negative mice express a cell surface phenotype consistent with aberrant positive selection or peripheral activation. Reconstitution of these mice with low levels of either the p31 or p41 form of Ii does not restore transport of the bulk of class II or class II surface expression, but surprisingly does restore positive selection as measured by numbers and surface phenotype of CD4+T cells. Thus, an li-dependent process, independent of effects on class II surface density, appears to be required for normal positive selection of CD4+T cells.