MicroRNAs from plants to animals, do they define a new messenger for communication?
MicroRNAs from plants to animals, do they define a new messenger for communication?
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从植物到动物的MicroRNA，它们是否定义了新的通讯信使？
DOI：
10.1186/s12986-018-0305-8
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发表时间：
2018
影响因子：
4.5
通讯作者：
Li N
中科院分区：
文献类型：
--
作者：
Li Z;Xu R;Li N
MicroRNA（miRNAs）是一类约22个核苷酸的单链非编码RNA，是存在于动植物中的基因表达的有效调控因子。最近的研究表明，植物miRNAs可以通过胃肠道进入哺乳动物的血流，并通过胃肠道进入受体的多种组织和细胞发挥治疗作用。这一有趣的现象表明，饮食/植物来源的miRNA可能作为一类新的生物活性成分与哺乳动物系统沟通。本文综述了miRNAs从食物/植物到动物传递的差异，并对miRNAs的产生途径和参与miRNAs功能的机制进行了比较。最后，对目前关于食物/植物来源的miRNAs的跨界调控和潜在的吸收和转运机制的争论进行了解释。此外，miRNAs的类神经递质作用以及miRNAs与激素之间复杂的相互作用也受到了牵连。最后，简要讨论了这些发现如何影响营养和医学。
MicroRNAs (miRNAs), a class of single-stranded non-coding RNA of about 22 nucleotides, are potent regulators of gene expression existing in both plants and animals. Recent studies showed that plant miRNAs could enter mammalian bloodstreamviagastrointestinal tract, through which access a variety of tissues and cells of recipients to exert therapeutic effects. This intriguing phenomenon indicates that miRNAs of diet/plant origin may act as a new class of bioactive ingredients communicating with mammalian systems. In this review, in order to pinpoint the reason underlying discrepancies of miRNAs transmission from diet/plant to animals, the pathways that generate miRNAs and machineries involved in the functions of miRNAs in both kingdoms were outlined and compared. Then, the current controversies concerning cross-kingdom regulations and the potential mechanisms responsible for absorption and transfer of diet/plant-derived miRNAs were interpreted. Furthermore, the hormone-like action of miRNAs and the intricate interplay between miRNAs and hormones were implicated. Finally, how these findings may impact nutrition and medicine were briefly discussed.
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影响因子：
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