Epicardial Progenitor Cells in Cardiac Development and Regeneration
Epicardial Progenitor Cells in Cardiac Development and Regeneration
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DOI：
10.1007/s12265-012-9377-4
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发表时间：
2012-10-01
影响因子：
3.4
通讯作者：
Brand, Thomas
中科院分区：
文献类型：
--
作者：
Schlueter, Jan;Brand, Thomas
心外膜在心脏表面形成一层上皮层。它来源于一群间皮细胞，被称为心前膜。心外膜不仅分化为心外膜，还分化为心外膜来源的细胞。这些细胞聚集在心肌壁，并分化为平滑肌细胞、成纤维细胞，可能还有内皮细胞。本文对心外膜的形成进行了讨论。介绍了适合在胚胎和成人中识别这些细胞的标记基因。最近的证据表明，PE由不同的细胞群组成。根据标记基因的表达可以区分这些细胞系，并且它们的分化潜能也不同。心外膜作为心脏干细胞来源的作用及其在心脏再生中的重要性也被讨论。
The epicardium forms an epithelial layer on the surface of the heart. It is derived from a cluster of mesothelial cells, which is termed the proepicardium. The proepicardium gives rise not only to the epicardium but also to epicardium-derived cells. These cells populate the myocardial wall and differentiate into smooth muscle cells, fibroblast, and possibly endothelial cells. In this review, the formation of the proepicardium is discussed. Marker genes, suitable to identify these cells in the embryo and in the adult, are introduced. Recent evidence suggests that the PE is made up of distinct cell populations. These cell lineages can be distinguished on the basis of marker gene expression and differ in their differentiation potential. The role of the epicardium as a resource for cardiac stem cells and its importance in cardiac regeneration is also discussed.