Adverse effects and outcome associated with dexamethasone administration in dogs with acute thoracolumbar intervertebral disk herniation: 161 cases (2000-2006)
Adverse effects and outcome associated with dexamethasone administration in dogs with acute thoracolumbar intervertebral disk herniation: 161 cases (2000-2006)
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DOI：
10.2460/javma.232.3.411
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发表时间：
2008-02-01
影响因子：
1.9
通讯作者：
Fosgate, Geoffrey T.
中科院分区：
文献类型：
--
作者：
Levine, Jonathan M.;Levine, Gwendolyn J.;Fosgate, Geoffrey T.
目的-确定对手术治疗胸腰椎椎间盘突出症的犬给予地塞米松相关的并发症和神经学结局，设计-回顾性病例系列，动物-161只经手术证实患有胸腰椎椎间盘突出症的狗，程序-来自2家医院的医疗记录用于识别入院前< 48小时接受地塞米松的狗（地塞米松组狗）、在入院前< 48小时接受除地塞米松以外的糖皮质激素的狗（其他糖皮质激素组狗）和不接受糖皮质激素的狗（非治疗组狗）。Significance，神经损伤等级，实验室数据和并发症提取的医疗records.Results-Dexamethasone组的狗有可能有并发症的3.4倍，与其他糖皮质激素或nontreatment组的狗。地塞米松组的狗患尿路感染的可能性是其他糖皮质激素或非治疗组的11.4倍，腹泻的可能性是3.5倍。出院时或复查评估的神经功能无差异检测groups.Conclusions和临床相关性，结果表明，手术前用地塞米松治疗与更多的不良反应，与糖皮质激素治疗比地塞米松或没有治疗与糖皮质激素相比，在犬胸腰椎椎间盘突出症。在该研究人群中，未发现组间结局差异。这些结果表明，地塞米松给药的价值术前犬胸腰椎间盘突出症应重新考虑。
Objective-To determine complications and neurologic outcomes associated with dexamethasone administration to dogs with surgically treated thoracolumbar intervertebral disk herniation, compared with dogs not receiving dexamethasone.Design-Retrospective case series.Animals-161 dogs with surgically confirmed thoracolumbar disk herniation.Procedures-Medical records from 2 hospitals were used to identify dogs that had received dexamethasone < 48 hours prior to admission (dexamethasone group dogs), dogs that received glucocorticoids other than dexamethasone < 48 hours prior to admission (other-glucocorticoid group dogs), and dogs that received no glucocorticoids (nontreatment group dogs). Signalment, neurologic injury grade, laboratory data, and complications were extracted from medical records.Results-Dexamethasone group dogs were 3.4 times as likely to have a complication, compared with other-glucocorticoid or nontreatment group dogs. Dexamethasone group dogs were 11.4 times as likely to have a urinary tract infection and 3.5 times as likely to have diarrhea, compared with other-glucocorticoid or nontreatment group dogs. No differences in neurologic function at discharge or recheck evaluation were detected among groups.Conclusions and Clinical Relevance-Results indicated that treatment with dexamethasone before surgery is associated with more adverse effects, compared with treatment with glucocorticoids other than dexamethasone or no treatment with glucocorticoids, in dogs with thoracolumbar intervertebral disk herniation. In this study population, no difference in outcome was found among groups. These findings suggest that the value of dexamethasone administration before surgery in dogs with thoracolumbar disk herniation should be reconsidered.