Hemodynamics in the abdominal aorta: a comparison of in vitro and in vivo measurements.
Hemodynamics in the abdominal aorta: a comparison of in vitro and in vivo measurements.
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DOI：
10.1152/jappl.1994.76.4.1520
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发表时间：
1994-04
影响因子：
3.3
通讯作者：
J. Moore;S. Maier;D. Ku;P. Boesiger
中科院分区：
文献类型：
--
作者：
J. Moore;S. Maier;D. Ku;P. Boesiger
体内血液流速剖面的测量很难获得和解释，因为控制通常高度复杂的流动情况的参数在测量时可能无法完全量化或理解。体外血流模型经常被用来更好地理解血管血流动力学。在设计这些模型时所作的假设限制了结果的适用性。在这项研究中，在精心设计的腹主动脉模型中进行的体外流量测量与磁共振成像获得的体内测量结果进行了比较。在离体和体内病例中，门上主动脉的速度分布均以前向和轴对称为主。两例肾下主动脉后壁附近均可见广泛的血流逆转。在主动脉分叉处，在侧后壁附近可观察到两个血流逆转峰，舒张后期观察到m型速度分布。体外和体内测量结果具有良好的定性一致性。体外模型能较准确地模拟腹主动脉的体内血流动力学。体内观察到的复杂现象是根据体外研究获得的知识来解释的。
In vivo measurements of blood velocity profiles are difficult to obtain and interpret, since the parameters that govern the normally highly complex flow situation may not be fully quantified or understood at the time of measurement. In vitro flow models have been used often to better understand vascular hemodynamics. The assumptions made in the design of these models limit the applicability of the results. In this study, in vitro flow measurements made in a carefully designed model of the abdominal aorta were compared with in vivo measurements obtained with magnetic resonance imaging. In the suprarenal aorta, the velocity profiles were mostly forward and axisymmetric in both the in vitro and in vivo cases. In the infrarenal aorta, there was extensive flow reversal noted near the posterior wall in both cases. In the aortic bifurcation, two peaks of flow reversal were noted near the lateral posterior walls, and M-shaped velocity profiles were observed in late diastole. The in vitro and in vivo measurements exhibited good qualitative agreement. The in vitro model was accurate in modeling the in vivo hemodynamics of the abdominal aorta. The complex phenomena observed in vivo were explained on the basis of knowledge gained from the in vitro study.