Effects of acute and chronic zinc exposure on steroid hormone receptor expression in the lined seahorse, Hippocampus erectus
Effects of acute and chronic zinc exposure on steroid hormone receptor expression in the lined seahorse, Hippocampus erectus
复制标题
DOI：
10.1111/jwas.12590
复制
发表时间：
2019-06
影响因子：
2.8
通讯作者：
Xue Han;Chunyan Li;G. Qin;Bo Zhang;Xin Wang;Q. Lin
中科院分区：
文献类型：
--
作者：
Xue Han;Chunyan Li;G. Qin;Bo Zhang;Xin Wang;Q. Lin
元素锌（Zn）可以引起动物的多种生理反应，特别是通过其对类固醇激素受体表达的影响。在这里，我们评估的影响，锌的类固醇激素受体的表达谱的内衬海马，海马直立，实验急性和慢性锌暴露。观察到复杂的反应模式;然而，12天锌注射（急性暴露）后肝脏和肾脏中的类固醇激素受体表达与对照治疗显著不同。对肝脏脂质代谢和肾脏渗透调节的明显影响需要详细研究。此外，49天（慢性）水溶性锌暴露导致雌激素受体（ER）表达水平和雌二醇浓度显著降低。此外，慢性暴露导致肝脏脂肪细胞的大量减少，这意味着锌可能通过ER和雌二醇调节肝脏脂质代谢。我们的研究证明了急性和慢性锌暴露对类固醇激素受体表达模式的影响，这将有助于理解锌诱导海马肝脏脂质代谢和其他生理反应的机制。
The element zinc (Zn) can elicit a variety of physiological responses in animals, particularly through its effects on steroid hormone receptor expression. Here, we evaluated the effects of Zn on the expression profiles of steroid hormone receptors in the lined seahorse,Hippocampus erectus, following experimental acute and chronic Zn exposure. Complex response patterns were observed; however, steroid hormone receptor expression in liver and kidney following 12‐day Zn injection (acute exposure) differed significantly from the control treatments. Apparent effects on hepatic lipid metabolism and osmotic regulation in the kidney need detailed investigation. Furthermore, 49‐day (chronic) waterborne Zn exposure produced a significant decrease in both estrogen receptor (ER) expression levels and estradiol concentrations. In additional, chronic exposure led to a substantial reduction of hepatic adipose cells, implying that Zn may regulate hepatic lipid metabolism via ER and estradiol. Our study demonstrated the effects of both acute and chronic Zn exposure on expression patterns of steroid hormone receptors, which will contribute to understanding the mechanism of Zn‐induced hepatic lipid metabolism and other physiological responses in seahorses.