HIPPOCAMPUS AMYGDALA VOLUMES AND PSYCHOPATHOLOGY IN CHRONIC-SCHIZOPHRENIA
HIPPOCAMPUS AMYGDALA VOLUMES AND PSYCHOPATHOLOGY IN CHRONIC-SCHIZOPHRENIA
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DOI：
10.1016/0006-3223(93)90289-p
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发表时间：
1993-02-15
影响因子：
10.6
通讯作者：
MASIAR, S
中科院分区：
文献类型：
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作者：
BOGERTS, B;LIEBERMAN, JA;MASIAR, S
对19例男性慢性多发性精神分裂症患者和18例年龄匹配的健康人的近颞叶结构(海马-杏仁核复合体)的体积进行了测量，采用3.1 mm宽的TL加权连续冠状磁共振图像。以乳头体水平为解剖学标志，将整个海马区-杏仁核复合体分为前部(主要含杏仁核组织)和后部(主要含海马结构)。与对照组(-11%)相比，患者组近颞叶组织总体积显著减少(-11%)，左侧(-20%)和右侧(-15%)海马切片均显著减少。边缘组织体积的减少与精神病理的严重程度相关。阳性精神病症状的严重程度(简明精神病评定量表[BPRS]精神病因子)与右侧和左侧近颞叶总体积显著相关(Spearman Rho‘s=-0.61p<；0.01)。阴性症状评分(BPRS神经痛因子、阴性症状评定量表[SANS]全球条目)与任何中颞叶组织体积均无显著相关，证实和扩展了前人关于精神分裂症颞缘结构体积减小的发现，提示精神分裂症的阳性精神病症状与中颞叶结构的解剖异常有关。
Volumes of the mesiotemporal structures (hippocampus-amygdala complex) were measured in 19 men who were chronic multiepisode schizophrenics and 18 age-matched healthy controls using Tl-weighted contiguous coronal magnetic resonance images of 3.1-mm width. Using the level of the mammillary bodies as an anatomical landmark, the whole hippocampus-amygdala complex was divided into an anterior section (mainly containing amygdaloid tissue) and a posterior section (mainly containing the hippocampal formation).Total mesiotemporal tissue volume was reduced significantly in the patient group compared to controls (-11%), with significant reductions in both left (-20%) and right (-15%) hippocampal sections. Reduced limbic tissue volume was associated with increased severity of psychopathology. Severity of positive psychotic symptoms (Brief Psychiatric Rating Scale [BPRS] psychosis factor) was correlated significantly with right and left total mesiotemporal volumes (Spearman rho's = -0.61 p < 0.01). Negative symptom scores (BPRS anergia factor, Scale for Assessment of Negative Symptoms [SANS] global items) were not significantly correlated with any mesiotemporal tissue volumes.The data corroborate and extend previous findings of temporolimbic structure volume reduction in schizophrenia, and suggest that the positive psychotic symptoms of schizophrenia are associated with anatomic anomalies in mesiotemporal structure.