Colorectal carcinomain vitro is more sensitive to 1-hexylcarbamoyl-5-fluorouracil compared with six other antitumor drugs: Carboquone, adriamycin®, mitomycin C, aclacinomycin A, cisplatin, 5-fluorouracil
Colorectal carcinomain vitro is more sensitive to 1-hexylcarbamoyl-5-fluorouracil compared with six other antitumor drugs: Carboquone, adriamycin®, mitomycin C, aclacinomycin A, cisplatin, 5-fluorouracil
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与其他六种抗肿瘤药物（卡波醌、阿霉素®、丝裂霉素 C、阿克拉霉素 A、顺铂、5-氟尿嘧啶）相比，体外结直肠癌对 1-己基氨基甲酰基-5-氟尿嘧啶更敏感
DOI：
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发表时间：
1988
影响因子：
3.9
通讯作者：
K. Sugimachi
中科院分区：
文献类型：
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作者：
Y. Maehara;H. Anai;H. Kusumoto;T. Kusumoto;K. Sugimachi
采用体外琥珀酸脱氢酶抑制试验（SDI），比较了25例大肠癌组织对1-己基氨基甲酰基-5-氟尿嘧啶（HCFU）和6种抗肿瘤药物：卡波醌（CQ）、阿霉素（ADM）、丝裂霉素C（MMC）、阿克拉霉素A（ACR）、顺铂（DDP）和5-氟尿嘧啶（5-FU）的敏感性。当暴露于药物的细胞的琥珀酸脱氢酶（SD）活性（10倍于血浆峰浓度）在暴露第3天降至对照细胞的50%以下时，化学敏感性被确定为阳性。与其他六种药物相比，在暴露于HCFU的情况下，SD活性降低是可接受的。敏感率分别为CQ 32%、ADM 40%、MMC 24%、ACR 28%、DDP 32%、5-FU 16%、HCFU68%。对6种药物（CQ、ADM、MMC、ACR、DDP和5-FU）中至少一种的敏感率为52%，但考虑到HCFU时为80%。由于结直肠癌组织对各种抗肿瘤药物具有耐药性，因此HCFU的化疗敏感性试验应有助于确定特定药物对个体患者的影响。
The sensitivity to 1-hexylcarbamoyl-5-fluorouracil (HCFU) of 25 colorectal cancer tissues was compared with that of six antitumor drugs: carboquone (CQ), Adriamycin® (ADM), mitomycin C (MMC), aclacinomycin A (ACR), cisplatin (DDP), and 5-fluorouracil (5-FU), using thein vitro succinate dehydrogenase inhibition (SDI) test. Chemosensitivity was determined to be positive when the succinate dehydrogenase (SD) activity of the drug-exposed cells, at ten times the peak plasma concentration, was decreased to below 50 percent of that of control cells on day 3 of exposure. Decrease in SD activity was remark-able in cases of exposure to HCFU, compared with six other drugs. The sensitivity rates were 32 percent for CQ, 40 percent for ADM, 24 percent for MMC, 28 percent for ACR, 32 percent for DDP, 16 percent for 5-FU, and 68 percent for HCFU. The sensitivity rate for at least one of the six drugs (CQ, ADM, MMC, ACR, DDP, and 5-FU) was 52 percent, but was 80 percent when HCFU was taken into account. Since colorectal cancer tissues are resistant to various antitumor drugs, the chemosensitivity test of HCFU should aid in determining the effects of a particular drug for an individual patient.
人类肿瘤克隆系统的前瞻性临床试验。
影响因子：
11.2
作者：
VonHoff,DD;Clark,GM;Stogdill,BJ;Sarosdy,MF;O'Brien,MT;Casper,JT;Mattox,DE;Page,CP;Cruz,AB;Sandbach,JF
通讯作者：
Sandbach,JF