ALTERED CD40 LIGAND INDUCTION IN TOLERANT T-LYMPHOCYTES
ALTERED CD40 LIGAND INDUCTION IN TOLERANT T-LYMPHOCYTES
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DOI：
10.1002/eji.1830251018
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发表时间：
1995-10-01
影响因子：
5.4
通讯作者：
QUILL, H
中科院分区：
文献类型：
--
作者：
BOWEN, F;HALUSKEY, J;QUILL, H
CD 40配体（CD 40 L）是肿瘤坏死因子超家族成员，表达于活化的T淋巴细胞表面。CD 40 L与B细胞上的CD 40相互作用导致B细胞活化、免疫球蛋白（IG）分泌和IG类别转换。为了研究无反应性作为小鼠CD 4 T细胞耐受的机制，我们在体内和体外确定了CD 3激活的无反应性细胞缺乏刺激B细胞增殖的能力，并且无反应性细胞缺乏T细胞受体/CD 3介导的CD 40 L表达的诱导。这些结果对无反应性T细胞在体内募集B细胞应答具有意义。
CD40 ligand (CD40L) is a member of the tumor necrosis factor superfamily and is expressed on the surface of activated T lymphocytes. The interaction of CD40L with CD40 on B cells results in B cell activation, immunoglobulin (Ig) secretion and Ig class switching. To study anergy as a mechanism of murine CD4 T cell tolerance, we determined both in vivo and in vitro that CD3-activated anergic cells are deficient in the ability to stimulate B cell proliferation, and that anergic cells are defective for the T cell receptor/CD3-mediated induction of CD40L expression. These results have implications for the recruitment of B cell responses by anergic T cells in vivo.