SHEAR-DEPENDENT THICKENING OF THE HUMAN ARTERIAL INTIMA
SHEAR-DEPENDENT THICKENING OF THE HUMAN ARTERIAL INTIMA
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DOI：
10.1016/0021-9150(86)90008-0
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发表时间：
1986-05-01
期刊：
影响因子：
5.3
通讯作者：
MARK, FF
中科院分区：
文献类型：
--
作者：
FRIEDMAN, MH;DETERS, OJ;MARK, FF
通过激光多普勒风速测定法在10个最小病变的人主动脉分叉的流通铸件中的163个位点获得血液动力学数据，并测量原始血管中这些位点中的每一个的内膜厚度（平均值= 208 μ m，范围= 10-967 μ m）。结果分析表明，暴露于高剪切应力的部位的内膜厚度迅速增加至适度值，此后缓慢增长，而暴露于低剪切应力的部位的厚度上升较慢，但经过一段时间后达到较高值。因此，年轻血管的内膜在剪切力高的地方较厚，而老年血管的内膜在剪切力低的地方较厚。这种行为是合理的一个吝啬的模型，其中一个物质从管腔进入壁和分解代谢或以其他方式删除。内膜通透性和内膜剥除率均随切应力的增加而增加。内膜厚度与壁中物质的量有关。该模型以105 μ m的总估计标准误差拟合实验数据。虽然该模型是一个极端简化的实际增稠过程，它表明，观察到的结果可能是竞争的剪切依赖过程的后果。
Hemodynamic data were obtained by laser Doppler anemometry at 163 sites in 10 flow-through casts of minimally diseased human aortic bifurcations, and the intimal thickness at each of these sites in the original vessels was measured (mean = 208 .mu.m, range = 10-967 .mu.m). Analysis of the results suggest that the intimal thickness at sites exposed to high shear stresses increases quickly to a modest value, growing slowly thereafter, while the thickness at sites exposed to low shears rises more slowly but, after time, reaches higher values. Thus the intima of younger vessels is thicker where shear is high, and that of older vessels is thicker where shear is low. This behavior is rationalized by a parsimonious model in which a substance from the lumen enters the wall and is catabolized or otherwise removed. The intimal permeability and removal rate both increase as the shear stress is raised. Intimal thickness is related to the amount of the substance in the wall. This model fits the experimental data with an overall standard error of estimate of 105 .mu.m. Although the model is an extreme simplification of the actual thickening process, it shows that the observed results can be the consequence of competing shear-dependent processes.