Bone Histomorphometric Study of Biopsied lliac Bone in Diabetic Patients
Bone Histomorphometric Study of Biopsied lliac Bone in Diabetic Patients
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糖尿病患者髂骨活检的骨组织形态学研究
DOI：
10.11393/jbmm1983.4.206
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Y. Gotō
中科院分区：
文献类型：
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作者：
Kozo Sato;Shigemitsu Arakawa;Yasuhisa Tanaka;Ken‐ichi Suzuki;Y. Gotō
本文对4例糖尿病并发症患者进行了放射学、生物化学和骨组织计量学检查，以阐明糖尿病与骨改变的关系，均为男性，1例骨质疏松伴病理性骨折，2例骨量减少。所有病例桡骨骨矿含量均较低，远1/6部位较明显。2例患者血浆1，25（OH）2D水平较低，24，25（OH）2D水平均较低。髂骨的组织形态计量学研究表明，在两个病例中，骨面积的骨密度值低于10%，另一个病例正常。所有病例的总吸收表面几乎正常，但未提供任何活性骨吸收的证据。在骨面积减少的病例中，总类骨质表面在正常范围内，但四环素的单标记和双标记很少，经常看到钙化不良的小梁单位，表明这些病例中的钙化紊乱。在骨面积正常的病例中，总的类骨质表面显著减少，但钙化率在正常值内或高于正常值，钙化似乎没有紊乱，但骨重建面积减少。随着糖尿病的加重和并发症的出现，骨质疏松症的发生也越来越明显。
Four diabetic patients with diabetic complications were examined to elucidate what kinds of bone changes were related to diabetes mellitus by radiological, biochemical and bone histomor pometric study.They were all male; one osteoporosis with pathological fracture and two osteopenia. Low radial bone mineral content was demonstrated in all cases, more evidently at the distal 1/6 part. Plasma 1, 25 (OH) 2D level was low in two and 24, 25 (OH) 2D level was low in all cases. Histomorphometric study of the iliac bone demonstrated osteoporotic value below 10% in bone area in two cases and normal in the other. The total resorption surface was almost normal in all the cases but did not provide any evidence of active bone resorption. The total osteoid surface was within normal in cases with decreased bone area, yet both single and double labeling of tetracycline were few and poorly calcified trabecular unit was frequently seen, suggesting disturbed calcification in these cases. In cases with normal bone area, the total osteoid surface remarkably decreased but the calcification rate was within or above the normal value, and the calcification appeared not disordered, though a bone remodelling area was reduced. It seems that apparent osteoporosis is likely to develop as diabetes mellitus is aggravating to accompany its complications.