Disrupted cerebellar development in preterm infants is associated with impaired neurodevelopmental outcome
Disrupted cerebellar development in preterm infants is associated with impaired neurodevelopmental outcome
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DOI：
10.1007/s00431-007-0647-0
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发表时间：
2008-10-01
影响因子：
3.6
通讯作者：
Birnbacher, Robert
中科院分区：
文献类型：
--
作者：
Messerschmidt, Agnes;Fuiko, Renate;Birnbacher, Robert
早产儿对发育中的小脑的不利影响最近被认识到，但作为早产儿相关并发症的小脑发育受损后的结果到目前为止还没有充分的文献记载。因此，我们将31名小脑发育受阻的早产儿与31名性别和胎龄匹配、小脑发育正常的早产儿作为对照组进行比较。新生儿期幕上脑损伤在两组间具有可比性。在最低年龄24个月时，通过标准化测试评估运动和智力发育。小脑发育受阻分别与神经运动(p<；0.001)和智力发育(p<；0.001)分项测试的分数显著降低有关。48%的患者被诊断为混合性CP，而对照组患者中没有一例出现混合性CP。小头畸形和癫痫与小脑发育障碍显著相关。在所有研究变量中，小脑发育受阻的早产儿结果较差。到目前为止，小脑在早产后神经发育中的作用似乎被低估了。
The unfavorable impact of prematurity on the developing cerebellum was recently recognized, but the outcome after impaired cerebellar development as a prematurity-related complication is hitherto not adequately documented. Therefore we compared 31 preterm patients with disrupted cerebellar development to a control group of 31 gender and gestational age matched premature infants with normal cerebellar development. Supratentorial brain injuries during the neonatal period were comparable between the groups. At a minimum age of 24 months motor and mental development was assessed by standardized tests. Disrupted cerebellar development was associated with significantly poorer scores both in the subtests for neuromotor (p < 0.001) and mental development (p < 0.001), respectively. Mixed CP was diagnosed in 48% of affected patients, whereas none of the patients of the control group had mixed CP. Microcephaly and epilepsy were significantly related to disrupted cerebellar development. Preterm patients with disrupted cerebellar development exhibit poorer outcome results in all investigated variables. The role of the cerebellum in neurodevelopment after prematurity seems to be underestimated so far.