Neuropathological changes of the nucleus accumbens in Huntington's chorea
Neuropathological changes of the nucleus accumbens in Huntington's chorea
复制标题
亨廷顿舞蹈症伏隔核的神经病理学改变
DOI：
10.1007/bf00691525
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发表时间：
2004
影响因子：
12.7
通讯作者：
G. Bruyn
中科院分区：
文献类型：
--
作者：
G. Bots;G. Bruyn
ncl的超微结构分析。10例亨廷顿舞蹈病患者的伏隔核、额叶皮质和尾状核中分别有25%、<5%和<2%的残余神经元元素的核膜压痕。在从阿尔茨海默病、帕金森病和非痴呆老年人中获得的10个非舞蹈性控制大脑中没有观察到这种现象。并讨论了导致这一现象的发病机制。
SummaryUltrastructural analysis of the ncl. accumbens, frontal cortex, and caudate nucleus of ten patients with Huntington's chorea revealed nuclear membrane indentation of remaining neuronal elements in >25%, <5%, and <2%, respectively. This phenomenon was not observed in ten non-choreic control brains obtained from patients with Alzheimer's disease, Parkinson's disease, and non-demented elderly people. The pathogenetic mechanisms leading to this phenomenon are discussed.