The effect of amygdala lesions on conditional and unconditional vocalizations in rats
The effect of amygdala lesions on conditional and unconditional vocalizations in rats
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DOI：
10.1016/s1074-7427(03)00002-9
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发表时间：
2003-05-01
影响因子：
2.7
通讯作者：
Leaton, RN
中科院分区：
文献类型：
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作者：
Borszcz, GS;Leaton, RN
以杏仁中央核（ACe）为中心的电解损伤导致大鼠无法获得巴甫洛夫条件性发声反应。条件反射包括配对的光条件刺激与尾震无条件刺激（US）。在条件反射之前，评估了对尾震的三种无条件反应（UR）的阈值。这些URs在脊髓（脊髓运动反射）、延髓（休克期间的发声）和前脑（发声后放电，VAD）水平的神经轴上组织。与假损伤对照组相比，杏仁核损伤的大鼠表现出选择性的VAD阈值升高。在条件反射过程中，杏仁核毁损大鼠VAD的幅度和持续时间选择性降低。这些发现支持了Borszcz（1993，1995 a）早期的观察，即尾震引起的VAD与这个US支持恐惧条件反射的能力相关。ACe可能参与恐惧条件反射的联想性和非联想性方面，但为了加深我们的理解，评估它在条件反射相关URs的产生中的作用至关重要。(C)2003 Elsevier Science（美国）。All rights reserved.
Electrolytic lesions centered on the amygdaloid central nucleus (ACe) resulted in the inability of rats to acquire a Pavlovian conditional vocalization response. Conditioning consisted of pairing a light conditional stimulus with a tailshock unconditional stimulus (US). The thresholds of three unconditional responses (URs) to tailshock were assessed prior to conditioning. These URs are organized at spinal (spinal motor reflexes), medullary (vocalizations during shock), and forebrain (vocalization afterdischarges, VADs) levels of the neuraxis. Compared to sham-lesioned controls, rats with amygdala lesions exhibited a selective elevation in the threshold of VADs. During conditioning the amplitude and duration of VADs were selectively reduced in amygdala-lesioned rats. These findings support earlier observations of Borszcz (1993, 1995a) that elicitation of VADs by tailshock correlates with the capacity of this US to support fear conditioning. The ACe may be involved in both associative and non-associative aspects of fear conditioning, but for progress in our understanding it is essential to evaluate its role in the generation of conditioning relevant URs. (C) 2003 Elsevier Science (USA). All rights reserved.