Polymorphisms in MMP9 and SIPA1 are associated with increased risk of nodal metastases in early-stage cervical cancer.
Polymorphisms in MMP9 and SIPA1 are associated with increased risk of nodal metastases in early-stage cervical cancer.
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DOI：
10.1016/j.ygyno.2009.09.037
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发表时间：
2010-03
影响因子：
4.7
通讯作者：
Rader JS
中科院分区：
文献类型：
--
作者：
Brooks R;Kizer N;Nguyen L;Jaishuen A;Wanat K;Nugent E;Grigsby P;Allsworth JE;Rader JS
遗传多态性调节癌症的转移效率。MMP 9（rs 17576）和SIPA 1（rs746429，rs 931127）的单核苷酸多态性（SNP）与多种癌症的淋巴结转移相关。我们研究了这些SNPs与早期宫颈癌淋巴结转移的关系。研究对象为同期行盆腔淋巴结清扫术的IB期宫颈癌患者。将病例（≥ 1例阳性LN，n=101）与对照组（LN病理阴性，n=273）进行比较。使用Taqman分析对3个SNP中的基因组DNA进行基因分型，并与临床变量相关。SIPA 1 rs 931127处的G等位基因与淋巴结疾病风险增加相关（OR 1.9，p=0.03），并且在SIPA 1 rs746429（OR 2.2，p=0.09）和MMP 9 rs 17576（OR 1.5，0.08）处接近显著性。在Ib 1期病变患者中（n=304），两个SIPA 1 SNP的G等位基因与LN转移相关（rs746429 OR 10.1，p=0.01; rs 931127 OR 2.4，p=0.01）。在无淋巴管间隙侵犯的患者中，SIPA 1 SNP再次与LN转移相关，所有淋巴结疾病患者在SIPA 1 rs746429处至少有一个G等位基因。在这个病例对照研究中，SIPA 1中的SNPs在有和没有淋巴结转移的宫颈癌患者中有统计学差异，在控制了分期和淋巴管浸润后，在MMP 9中也有统计学差异。需要进一步的工作来表征遗传多态性，为转移级联提供允许的背景。
Heritable polymorphisms modulate metastatic efficiency in cancer. Single nucleotide polymorphisms (SNPs) in MMP9 (rs17576) and SIPA1 (rs746429, rs931127) have been associated with nodal metastases in multiple cancers. We investigated the association of these SNPs with nodal metastases in early stage cervical cancer. Consecutive patients with stage IB cervical cancer who underwent a pelvic lymph node (LN) dissection were included. Cases (≥ 1 positive LN, n=101) were compared with controls (negative LN pathology, n=273). Genotyping was performed on genomic DNA in the 3 SNPs using a Taqman assay, and correlated with clinical variables. The G allele at SIPA1 rs931127 was associated with an increased risk of nodal disease (OR 1.9, p=0.03), and approached significance at SIPA 1 rs746429 (OR 2.2, p=0.09) and MMP9 rs17576 (OR 1.5, 0.08). In patients with stage Ib1 lesions (n=304), the G allele at both SIPA1 SNPs were associated with LN metastases (rs746429 OR 10.1, p=0.01; rs931127 OR 2.4, p=0.01). In patients with no lymph vascular space invasion, SIPA1 SNPs were again associated with LN metastases, and all patients with nodal disease had at least one G allele at SIPA1 rs746429. In this case control study, SNPs in SIPA1 varied statistically in cervical cancer patients with and without nodal metastases, and in MMP9 after controlling for stage and lymphvascular space invasion. Further work is needed to characterize inherited polymorphisms that provide a permissive background for the metastatic cascade.
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DOI：
10.3109/02841868409136048
发表时间：
1984-01-01
期刊：
ACTA RADIOLOGICA ONCOLOGY
影响因子：
--
作者：
TANAKA, Y;SAWADA, S;MURATA, T
通讯作者：
MURATA, T
皮肤恶性黑色素瘤患者的基质金属蛋白酶9（MMP-9）多态性。
影响因子：
--
作者：
Cotignola, Javier;Reva, Boris;Mitra, Nandita;Ishill, Nicole;Chuai, Shaokun;Patel, Ami;Shah, Shivang;Vanderbeek, Gretchen;Coit, Daniel;Busam, Klaus;Halpern, Allan;Houghton, Alan;Sander, Chris;Berwick, Marianne;Orlow, Irene
通讯作者：
Orlow, Irene
影响因子：
4.8
作者：
Tsukamoto, N;Hattori, M;Minato, N
通讯作者：
Minato, N
影响因子：
11.2
作者：
Deryugina, EI;Zijlstra, A;Quigley, JP
通讯作者：
Quigley, JP
影响因子：
11.2
作者：
Chantrain, CF;Shimada, H;DeClerck, YA
通讯作者：
DeClerck, YA