MAREK DISEASE VIRUS ENCODES A BASIC-LEUCINE ZIPPER GENE RESEMBLING THE FOS/JUN ONCOGENES THAT IS HIGHLY EXPRESSED IN LYMPHOBLASTOID TUMORS
MAREK DISEASE VIRUS ENCODES A BASIC-LEUCINE ZIPPER GENE RESEMBLING THE FOS/JUN ONCOGENES THAT IS HIGHLY EXPRESSED IN LYMPHOBLASTOID TUMORS
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DOI：
10.1073/pnas.89.9.4042
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发表时间：
1992-05-01
影响因子：
11.1
通讯作者：
TILLOTSON, JK
中科院分区：
文献类型：
--
作者：
JONES, D;LEE, L;TILLOTSON, JK
马立克氏病病毒（MDV）是一种鸡疱疹病毒，在感染后3周内诱导T淋巴瘤。MDV诱导的肿瘤的短潜伏期和多克隆性质表明，该病毒可能编码一个或多个直接作用的癌基因。然而，迄今为止，没有MDV特异性肿瘤抗原或候选转化基因已被证明。在本文中，我们报告的鉴定MDV基因编码的蛋白质具有同源性的亮氨酸拉链类的核癌基因。它还含有另一类转录因子特有的富含脯氨酸的结构域。该基因被命名为meq，定位于MDV的长重复序列，并且是在MDV诱导的T细胞肿瘤中高度表达的少数基因之一。据我们所知，疱疹病毒基因密切相关的fos/jun家族的癌基因还没有以前的报道。
Marek disease virus (MDV) is a herpesvirus of chickens that induces T lymphomas within 3 weeks of infection. The short latency and polyclonal nature of MDV-induced tumors have suggested that the virus may encode one or more direct-acting oncogenes. To date, however, no MDV-specific tumor antigens or candidate transforming genes have been demonstrated. In this paper, we report the identification of a MDV gene encoding a protein with homology to the leucine-zipper class of nuclear oncogenes. It also contains a proline-rich domain characteristic of another class of transcription factors. This gene, designated meq, maps to the long repeat of MDV and is one of the few genes that are highly expressed in MDV-induced T-cell tumors. To our knowledge, a herpesvirus gene closely related to the fos/jun family of oncogenes has not been reported previously.