Development and cell response of a new biodegradable composite scaffold for guided bone regeneration
Development and cell response of a new biodegradable composite scaffold for guided bone regeneration
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DOI：
10.1023/b:jmsm.0000021113.88702.9d
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发表时间：
2004-04-01
影响因子：
3.7
通讯作者：
Ambrosio, L
中科院分区：
文献类型：
--
作者：
Navarro, M;Ginebra, MP;Ambrosio, L
生物可降解聚合物与不同的磷酸钙陶瓷和玻璃的复合材料已被开发为骨组织工程应用的支架材料。在本工作中，将磷酸盐玻璃颗粒引入到聚合物中，阐述了聚(95L/5DL)乳酸(PLA)及其多孔结构。对材料的孔隙率、压缩力学性能和生物响应进行了评价。得到了孔道分布均匀、孔隙率高达97%的互连结构。聚合物中玻璃颗粒的加入对泡沫塑料的力学性能有积极的影响。事实上，聚乳酸和聚乳酸/泡沫玻璃的压缩模数分别从74.5提高到120kpa，抗压强度从17.5kpa提高到20.1kpa。通过四甲基偶氮唑盐比色法对材料的生物反应进行评价，结果表明材料无细胞毒性。(C)2004年克鲁沃学术出版社。
Composites of biodegradable polymers with different calcium phosphate ceramics and glasses, have been developed as scaffolds for applications in bone-tissue engineering. In this work, phosphate glass particles have been incorporated into the polymer, poly(95L/5DL) lactic acid (PLA) and porous structures were elaborated. Their porosity, compressive mechanical properties and biological response were evaluated. Interconnected structures with evenly distributed pores and a porosity as high as 97% were obtained. The incorporation of glass particles into the polymer showed to have a positive effect in the mechanical properties of the foams. Indeed, the compressive modulus increased from 74.5 to 120 KPa and the compressive strength from 17.5 to 20.1 KPa for the PLA and the PLA/glass foams, respectively. The biological response was evaluated by means of the MTT test, the materials resulted to be noncytotoxic. (C) 2004 Kluwer Academic Publishers.