BETA-NAP, A CEREBELLAR DEGENERATION ANTIGEN, IS A NEURON-SPECIFIC VESICLE COAT PROTEIN
BETA-NAP, A CEREBELLAR DEGENERATION ANTIGEN, IS A NEURON-SPECIFIC VESICLE COAT PROTEIN
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DOI：
10.1016/0092-8674(95)90474-3
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发表时间：
1995-09-08
期刊：
影响因子：
64.5
通讯作者：
DARNELL, RB
中科院分区：
文献类型：
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作者：
NEWMAN, LS;MCKEEVER, MO;DARNELL, RB
我们已经确定了自身免疫性小脑变性，β-NAP，这是密切相关的β-适应素和β-COP外壳蛋白的靶抗原。β-NAP是一种非网格蛋白相关的磷蛋白，从E12到成年仅在神经元中表达。β-NAP作为可溶性和膜结合池存在于神经元索马和神经末梢中，并与一组离散的神经末梢囊泡相关。这些结果确立了β-NAP作为神经元特异性囊泡外壳蛋白。我们提出了一个模型，其中β-NAP介导的囊泡之间的运输的索马和轴突末端，并建议β-NAP可能代表了一般类的外壳蛋白介导的顶端运输极化细胞。
We have identified a target antigen in autoimmune cerebellar degeneration, beta-NAP, that is closely related to the beta-adaptin and beta-COP coat proteins. beta-NAP is a non-clathrin-associated phosphoprotein expressed exclusively in neurons, from E12 through adulthood. beta-NAP is present in the neuronal soma and nerve terminal as soluble and membrane-bound pools and is associated with a discrete set of nerve-terminal vesicles. These results establish beta-NAP as a neuron-specific vesicle coat protein. We propose a model in which beta-NAP mediates vesicle transport between the soma and the axon terminus and suggest that beta-NAP may represent a general class of coat proteins that mediates apical transport in polarized cells.