SERUM LEVELS OF D-NORGESTREL, LUTEINIZING-HORMONE, FOLLICLE-STIMULATING-HORMONE, ESTRADIOL, AND PROGESTERONE IN WOMEN DURING AND FOLLOWING INGESTION OF COMBINATION ORAL-CONTRACEPTIVES CONTAINING DL-NORGESTREL
SERUM LEVELS OF D-NORGESTREL, LUTEINIZING-HORMONE, FOLLICLE-STIMULATING-HORMONE, ESTRADIOL, AND PROGESTERONE IN WOMEN DURING AND FOLLOWING INGESTION OF COMBINATION ORAL-CONTRACEPTIVES CONTAINING DL-NORGESTREL
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DOI：
10.1016/0002-9378(77)90733-5
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发表时间：
1977-01-01
影响因子：
9.8
通讯作者：
GOEBELSMANN, U
中科院分区：
文献类型：
--
作者：
BRENNER, PF;MISHELL, DR;GOEBELSMANN, U
Formulations (3) of dl-norgestrel were administered daily to groups of 3 women for 5 consecutive days. The serum levels of d-norgestrel were related to dosage of dl-norgestrel ingested. Peak concentrations in circulation of synthetic gestagen were attained a .5-3 h after oral administration, followed by a rapid and sharp decline in levels until the next dose. Three women received 500 .mu.g of dl-norgestrel and 50 .mu.g of ethinyl estradiol for 21 days followed by 6-7 days of no medication for 2 consecutive cycles. Gonadotropins remained suppressed for 4-6 days when therapy was discontinued. Daily concentrations of estradiol varied from less than 5-81 pg/ml, and there was no differnece in estrogen values during nontreatment and treatment days. Due to the long half life of norgestrel, the 1-wk pill-free interval is not long enough for complete recovery of the reproductive axis from inhibition of oral contraceptives.
