Effects of L-364,718, a new cholecystokinin receptor antagonist, on camostate-induced growth of the rat pancreas.
Effects of L-364,718, a new cholecystokinin receptor antagonist, on camostate-induced growth of the rat pancreas.
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L-364,718（一种新型胆囊收缩素受体拮抗剂）对 Camostate 诱导的大鼠胰腺生长的影响。
DOI：
10.1016/0016-5085(88)90617-8
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发表时间：
1988
期刊：
影响因子：
29.4
通讯作者：
Renner,IG
中科院分区：
文献类型：
--
作者：
WisnerJr,JR;McLaughlin,RE;Rich,KA;Ozawa,S;Renner,IG
长期喂食卡莫司特导致胰腺肥大或增生，或两者兼而有之。先前的研究表明，卡莫司特的这种作用是通过增加内源性胆囊收缩素而发生的，这是由于肠内反馈机制涉及抑制十二指肠中的胰蛋白酶。使用丙谷胺（一种较弱且相对非特异性的胆囊收缩素拮抗剂）的研究未能完全消除卡莫司特诱导的胰腺生长。我们研究了L-364，718，一种新的高效胆囊收缩素受体拮抗剂，对卡莫司特诱导的大鼠胰腺生长的影响。胰腺重量和核糖核酸，蛋白质和胰凝乳蛋白酶原的浓度与camostate单独处理的大鼠胰腺中显着升高的控制。在用卡莫司特+ L-364，718处理的大鼠中，卡莫司特的这些作用完全消除。L-364，718单独给药大鼠的胰腺重量以及胰腺中脱氧核糖核酸和核糖核酸的浓度显著低于对照大鼠的值。这些数据表明，camostate诱导的胰腺生长的大鼠似乎是依赖于内源性胆囊收缩素的行动，胆囊收缩素可能发挥作用，在正常大鼠胰腺生长的维护。
Chronic feeding of rats with camostate results in pancreatic hypertrophy or hyperplasia, or both. Previous studies suggest that this effect of camostate occurs via an increase in endogenous cholecystokinin due to an enteral feedback mechanism involving the inhibition of trypsin in the duodenum. Studies employing proglumide, a weak and relatively nonspecific cholecystokinin antagonist, have failed to fully abolish camostate-induced pancreas growth. We examined the effects of L-364,718, a new and highly potent cholecystokinin receptor antagonist, on camostate-induced pancreas growth in rats. The pancreas weights and the concentrations of ribonucleic acid, protein, and chymotrypsinogen in the pancreas of rats treated with camostate alone were significantly elevated over those of controls. These effects of camostate were completely abolished in rats treated with camostate + L-364,718. The pancreas weights and the concentrations of deoxyribonucleic acid and ribonucleic acid in the pancreas of rats treated with L-364,718 alone were significantly lower than values in control rats. These data indicate that camostate-induced pancreas growth in rats appears to be dependent on the actions of endogenous cholecystokinin and that cholecystokinin may play a role in the maintenance of pancreatic growth in normal rats.
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DOI：
10.1016/j.bjps.2006.04.017
发表时间：
2007-01-01
影响因子：
2.7
作者：
Wilson, Andrew D. H.;Hart, Andrew;Terenghi, Giorgio
通讯作者：
Terenghi, Giorgio
DOI：
10.1111/j.1749-6632.2005.tb00021.x
发表时间：
2005-08
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影响因子：
4.8
作者：
S. Pande;M. Blanchaer
通讯作者：
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影响因子：
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作者：
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DOI：
--
发表时间：
1994
期刊：
Drugs under experimental and clinical research
影响因子：
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作者：
G. Salvioli;M. Neri
通讯作者：
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