Association of sarcopenia and muscle mass with both peripheral neuropathy and nerve function in patients with type 2 diabetes
Association of sarcopenia and muscle mass with both peripheral neuropathy and nerve function in patients with type 2 diabetes
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DOI：
10.1016/j.diabres.2020.108096
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发表时间：
2020-04-01
影响因子：
5.1
通讯作者：
Yan, Sunjie
中科院分区：
文献类型：
--
作者：
Zhang, Yongze;Shen, Ximei;Yan, Sunjie
目的：本研究旨在探讨2型糖尿病患者肌肉减少和肌肉质量与周围神经病变和神经功能的关系。入选2型糖尿病患者（男性937例，女性857例），平均年龄60.22岁，进行横断面研究;其中，183名患者参加了随访研究，中位随访时间为2.7年。所有参与者都进行了神经传导研究和肌肉质量指数（ASM/HT 2）测量。计算感觉神经传导速度（SCV）和运动神经传导速度（MCV）的复合Z评分。ASM/HT 2、SCV和MCV的变化是根据近2年的测量结果计算的，并分为三组：ASM/HT 2下降> 3%，+/-3%范围内的微小变化，以及ASM/HT 2增加> 3%。男性的ASM/HT 2与MCV和SCV的综合Z评分呈正相关，在调整混杂因素后，肌肉减少症与DPN高度相关。ASM/HT 2显示DPN的最佳临界点为7.09 kg/m2。此外，ASM/HT 2的增加独立预测MCV和SCV增量结局的更大益处，而ASM/HT 2的微小变化仅与SCV增量方面的较低益处显著相关。结论：肌肉减少症与DPN有密切关系。肌肉质量的增加改善了部分MCV和SCV。然而，在这一现象中观察到与性别有关的差异。(C)2020爱思唯尔B. V.保留所有权利。
Aim: This study aimed to investigate the association of sarcopenia and muscle mass with both peripheral neuropathy and nerve function in type 2 diabetes mellitus.Methods: A total of 1794 patients (937 men and 857 women) with type 2 diabetes, with a mean age of 60.22 years, were enrolled for a cross-sectional study; of these, 183 patients were enrolled for a follow-up study with a median follow-up of 2.7 years. All participants underwent nerve conduction studies and muscle mass index (ASM/HT2) measurements. The composite Z scores for the sensory nerve conduction velocity (SCV) and the motor nerve conduction velocity (MCV) were calculated. The changes in ASM/HT2, SCV, and MCV were calculated from the measurements nearly 2 years apart and classified into three groups: a decrease in ASM/HT2 of >3%, a minor change within +/- 3%, and an increase in ASM/HT2 of >3%.Results: The ASM/HT2 of men was positively associated with the composite Z scores of MCV and SCV, and sarcopenia highly correlated with DPN after adjusting for confounding factors. The optimal cutoff point for ASM/HT2 that indicated DPN was 7.09 kg/m(2). Furthermore, increases in ASM/HT2 independently predicted a greater benefit of MCV and SCV increment outcomes, whereas a minor change in ASM/HT2 only significantly associated with lower benefit in terms of SCV increment. However, this phenomenon was not observed in women.Conclusions: Sarcopenia and DPN exhibited a close association. The increased muscle mass improved the partial MCVs and SCVs. However, a sex-related discrepancy was observed in this phenomenon. (C) 2020 Elsevier B.V. All rights reserved.