Effects of circulating norepinephrine on platelet, leukocyte and red blood cell counts by alpha 1-adrenergic stimulation.
Effects of circulating norepinephrine on platelet, leukocyte and red blood cell counts by alpha 1-adrenergic stimulation.
复制标题
α1-肾上腺素能刺激循环去甲肾上腺素对血小板、白细胞和红细胞计数的影响。
DOI：
10.1016/0002-9149(89)90096-9
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
IzzoJr,JL
中科院分区：
文献类型：
--
作者：
Sloand,JA;Hooper,M;IzzoJr,JL
过去，去甲肾上腺素（NE）通常被认为是一种神经递质，而不是一种激素。这一观点主要基于对中间代谢和葡萄糖反调节的研究。然而，从心血管系统的角度来看，NE的潜在体液作用可能被低估了。we2和其他人已经证明循环NE在调节肾脏肾素释放方面很重要。我们还发现，在NE输注期间，红细胞压积持续增加2，并推断，如果循环NE是一种真正的“应激激素”，那么血小板和白细胞计数的应激相关增加也可能依赖于NE。对心血管发病率和死亡率的明显影响促使这些初步研究调查NE对血液元素的激素影响。
In the past, norepinephrine (NE) has generally been considered to serve more as a neurotransmitter than as a a hormone.1This notion has been based largely on studies of intermediary metabolism and glucose counterregulation. However, from the point of view of the cardiovascular system, the potential humoral role of NE may have been underestimated. We2and others3have demonstrated that circulating NE is important in regulating renal renin release. We have also found a consistent increase in hematocrit during NE infusion,2and have reasoned that if circulating NE is a true “stress hormone,” then stress-related increases in platelet and leukocyte counts could also be NE-dependent. The obvious implications for cardiovascular morbidity and mortality prompted these preliminary studies to investigate hormonal effects of NE on blood elements.