ANTIOXIDANT ACTIVITY AND STABILITY OF 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID
ANTIOXIDANT ACTIVITY AND STABILITY OF 6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-2-CARBOXYLIC ACID
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DOI：
10.1007/bf02672164
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发表时间：
1975-01-01
影响因子：
2
通讯作者：
POOL, WR
中科院分区：
文献类型：
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作者：
CORT, WM;SCOTT, JW;POOL, WR
在植物油和动物脂肪的薄层试验中，6-羟基-2,5,7,8-四甲基铬-2-羧酸的抗氧化活性是丁基羟基甲苯和丁基羟基异醇的2- 4倍，比没食子酸丙酯、去二氢醌酸、抗坏血酸棕榈酸酯和α-和γ-生育酚更有活性。在薄层试验中，它也比鸡和猪肉脂肪以及玉米、花生、向日葵和红花油中的叔丁基对苯二酚更有活性。叔丁基对苯二酚在玉米、大豆、棉籽和花生油中的活性略高，可能是由于在98℃时铬酸分解，这种分解被抗坏血酸抑制。该色素由抗坏血酸棕榈酸硫代二丙酸和抗坏血酸协同作用。与后者结合，得到190小时的活性氧法值。建立了6-羟基-2,5,7,8-四甲基铬-2-羧酸的荧光光谱测定方法。该化合物在室温和45℃下2个月的稳定性为95-100%，毒性较低。测定了铬的铜和铁的分解产物。介绍了抗坏血酸和乙二胺四乙酸对人体的保护作用及其作用机理。
6-Hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid in thin layer tests in vegetable oils and animal fats has two-four times the antioxidant activity of butylated hydroxytoluene and butylated hydroxyanisole and is more active than propyl gallate, nordihydroquaiaretic acid, ascorbyl palmitate, and α- and γ-tocopherols. It is also more active than tertiary butylhydroquinone in chicken and pork fats and corn, peanut, sunflower, and safflower oils in thin layer tests. Tertiary butylhydroquinone is slightly more active in corn, soybean, cottonseed, and peanut oils in the active oxygen method, probably due to decomposition of the chroman at 98 C. This decomposition is inhibited by ascorbic acid. The chroman is synergized by ascorbyl palmitate-thiodipropionate and ascorbic acids. Active oxygen method values of 190 hr are obtained in combination with the latter. A spectrofluorometric assay for 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid has been developed. The compound is 95–100% stable for 2 months at room temperature and 45 C, and a low level of toxicity is found. The copper and iron breakdown products of the chroman have been determined. A possible relationship between these products, protection of the chroman by ascorbic acid and ethylene diaminetetraacetic acid, and a mechanism of action is presented.