Origins of the domestic dog and the rich potential for gene mapping.
Origins of the domestic dog and the rich potential for gene mapping.
复制标题
DOI：
10.4061/2011/579308
复制
发表时间：
2011
影响因子：
--
通讯作者：
Wilton AN
中科院分区：
文献类型：
--
作者：
Shearman JR;Wilton AN
家犬独特的繁殖结构使犬遗传学成为进一步了解遗传性疾病和基因功能的有用工具。狗是何时何地从狼驯化而来的问题的答案尚不确定，但现代狗品种的多样性是如何发展的却有记录。品种发展产生了许多基因分离的种群，这些种群因疾病、形态和行为特征的不同等位基因而分离。许多遗传工具可用于狗研究，从而可以调查这些表型的遗传基础。对狗疾病原因的研究与人类和其他物种相关；比较基因组学被用来向它们传递遗传信息，包括一些关于形态和行为表型的研究。由于独特的品种结构和维护良好的血统，狗代表了包含丰富遗传信息的模式生物。
The unique breeding structure of the domestic dog makes canine genetics a useful tool to further the understanding of inherited diseases and gene function. Answers to the questions of when and where the dog was domesticated from the wolf are uncertain, but how the modern diversity of dog breeds was developed is documented. Breed development has resulted in many genetically isolated populations which are segregating for different alleles for disease and morphological and behavioral traits. Many genetic tools are available for dog research allowing investigation into the genetic basis of these phenotypes. Research into causes of diseases in dogs is relevant to humans and other species; comparative genomics is being used to transfer genetic information to them, including some studies on morphological and behavioral phenotypes. Because of the unique breed structure and well-maintained pedigrees, dogs represent a model organism containing a wealth of genetic information.