Interindividual uniformity and variety of the “Writing center”: A functional MRI study
Interindividual uniformity and variety of the “Writing center”: A functional MRI study
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DOI：
10.1016/j.neuroimage.2006.05.035
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发表时间：
2006-10
期刊：
影响因子：
5.7
通讯作者：
Genichi Sugihara;T. Kaminaga;M. Sugishita
中科院分区：
文献类型：
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作者：
Genichi Sugihara;T. Kaminaga;M. Sugishita
我们的目标是使用功能磁共振成像(20名右撇子受试者)来研究书写的神经基础。我们假设右手和左手书写的共同区域对写作的中心过程至关重要。我们使用了日语语音(假名)，其中音素到字素的转换将非常简单。实验采用三种条件：(1)右手书写命名(WR)，(2)左手书写命名(WL)，(3)默默命名(NA)。与NA相比，WR和NA仅在左额顶区激活，而WL和NA比较显示出比WR和NA更广泛的激活，即除运动和感觉区域外的左侧额顶区域和右侧额顶区域。SPM2中的一项联合分析显示，在WR和WL的比较中，存在共同的激活区域，这被认为对写作至关重要。在组分析中，发现三个区域被激活：左额上回的后端，位于Exner‘s中心的上方和后方；左顶上小叶的前部；和左缘上回的前肢的下部。在单一受试者的分析中，尽管上述三个区域中的前两个区域被发现对所有个体的写作至关重要，但在三个区域观察到个体间参与与写作的不一致：左侧边缘上回前肢的下部(60%受累)；右侧额区(47%)；以及右侧顶内沟(47%)。
Our aim is to investigate the neural substrates for writing using fMRI (twenty right-handed subjects). We assumed that common areas involved in both writing with right and left hands are crucial to the central process of writing. We employed Japanese phonograms (Kana), in which phoneme–grapheme conversion would be extremely simple. Brain activation was examined under three conditions: (1) written naming with the right hand (WR), (2) written naming with the left hand (WL), and (3) naming silently (NA). While the comparison of WR to NA (WR > NA) exhibited activation only in the left frontoparietal area, the WL > NA comparison exhibited broader activation than the WR > NA comparison, i.e., the left frontoparietal area except the motor and sensory areas and the right frontoparietal area. A conjunction analysis in SPM2 revealed common areas of activation across the WR > NA and WL > NA comparisons, which are assumed to be crucial to writing. In the group analysis, three areas were found to be activated: the posterior end of the left superior frontal gyrus, which is superior and posterior to Exner's center; the anterior part of the left superior parietal lobule; and the lower part of the anterior limb of the left supramarginal gyrus. In the single-subject analysis, whereas the first two of the above three areas were found to be crucial for writing in all individuals, an interindividual inconsistency of involvement with writing was observed in three areas: the lower part of the anterior limb of the left supramarginal gyrus (60% involved); the right frontal region (47%); and the right intraparietal sulcus (47%).