Replenishable drug depot to combat post-resection cancer recurrence.
Replenishable drug depot to combat post-resection cancer recurrence.
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DOI：
10.1016/j.biomaterials.2018.05.005
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发表时间：
2018-09
期刊：
影响因子：
14
通讯作者：
Mooney DJ
中科院分区：
文献类型：
--
作者：
Brudno Y;Pezone MJ;Snyder TK;Uzun O;Moody CT;Aizenberg M;Mooney DJ
药物洗脱库使局部药物呈现成为可能，已证明对多种疾病有好处，包括癌症、微生物感染和伤口愈合。然而，局部洗脱储库是一次性系统，在植入难以到达的部位后无法重新填充或重复使用，限制了其临床实用性。无创再填充药物洗脱库的新策略可以极大地增强其临床应用。在本报告中，我们提出了一种基于生物正交点击化学的可再填充水凝胶储库系统。点击修饰的水凝胶储库从血液中捕获前药补充物，随后以持续的方式局部释放活性药物。捕获系统给药的补充品是一种有效且无毒的重复补充储存库的方法。可再填充的储库与前药再填充相结合，可在癌前肿瘤部位实现持续释放，以改善癌症治疗，同时消除全身副作用。在不增强渗透性的情况下靶向组织的能力可以允许在癌症和许多其他医疗应用中使用可再填充的储库。
Local drug presentation made possible by drug-eluting depots has demonstrated benefits in a vast array of diseases, including in cancer, microbial infection and in wound healing. However, locally-eluting depots are single-use systems that cannot be refilled or reused after implantation at inaccessible sites, limiting their clinical utility. New strategies to noninvasively refill drug-eluting depots could dramatically enhance their clinical use. In this report we present a refillable hydrogel depot system based on bioorthogonal click chemistry. The click-modified hydrogel depots capture prodrug refills from the blood and subsequently release active drugs locally in a sustained manner. Capture of the systemically-administered refills serves as an efficient and non-toxic method to repeatedly refill depots. Refillable depots in combination with prodrug refills achieve sustained release at precancerous tumor sites to improve cancer therapy while eliminating systemic side effects. The ability to target tissues without enhanced permeability could allow the use of refillable depots in cancer and many other medical applications.
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影响因子：
16.1
作者：
Au JL;Yeung BZ;Wientjes MG;Lu Z;Wientjes MG
通讯作者：
Wientjes MG
影响因子：
28.2
作者：
Incio J;Liu H;Suboj P;Chin SM;Chen IX;Pinter M;Ng MR;Nia HT;Grahovac J;Kao S;Babykutty S;Huang Y;Jung K;Rahbari NN;Han X;Chauhan VP;Martin JD;Kahn J;Huang P;Desphande V;Michaelson J;Michelakos TP;Ferrone CR;Soares R;Boucher Y;Fukumura D;Jain RK
通讯作者：
Jain RK
影响因子：
2.7
作者：
Henne, Walter A.;Doorneweerd, Derek D.;Low, Philip S.
通讯作者：
Low, Philip S.
DOI：
10.1073/pnas.1113466109
发表时间：
2012-03-27
影响因子：
11.1
作者：
Devaraj, Neal K.;Thurber, Greg M.;Weissleder, Ralph
通讯作者：
Weissleder, Ralph
影响因子：
2.4
作者：
Crispino, Pietro;De Toma, Giorgio;Paoluzi, Paolo
通讯作者：
Paoluzi, Paolo