Characterization of rabbit ear artery opioid receptors using a delta-selective agonist and antagonist.
Characterization of rabbit ear artery opioid receptors using a delta-selective agonist and antagonist.
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DOI：
10.1016/0014-2999(87)90497-3
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发表时间：
1987-07
影响因子：
5
通讯作者：
I. Berzétei;H. Yamamura;S. Duckles
中科院分区：
文献类型：
--
作者：
I. Berzétei;H. Yamamura;S. Duckles
为了表征兔耳动脉交界前δ阿片受体，采用δ选择性激动剂[D-Pen2，D-Pen5]脑啡肽（DPDPE）和δ选择性拮抗剂ICI 174,864。这些化合物对δ受体的选择性是用标准的阿片敏感制剂，小鼠被证实。一系列阿片受体激动剂在兔耳动脉和小鼠输精管中的相对效价相似。此外，IC 174,864的kvalue在两种组织中没有差异。这些结果表明，兔耳动脉和小鼠输精管中的δ阿片受体具有相似的特性。
In order to characterize pre-junctional δ opioid receptors in the rabbit ear artery, the δ-selective agonist [D-Pen2,D-Pen5]enkephalin (DPDPE), and δ-selective antagonist, ICI 174,864, were used. The selectivity of these compounds for the δ receptor was confirmed using a standard opioid sensitive preparation, the mouse was deferens. Relative potencies of a series of opioid agonists were similar in the rabbit ear artery and the mouse vas deferens. Furthermore, Kevalues for IC 174,864 were not different in the two tissues. These findings demonstrate that δ opioid receptors in the rabbit ear artery and mouse vas deferens have similar properties.