Nanofibers in a hyaluronan-based pericellular matrix
Nanofibers in a hyaluronan-based pericellular matrix
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DOI：
10.1016/j.matbio.2010.08.006
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发表时间：
2010-10-01
期刊：
影响因子：
6.9
通讯作者：
Kappler, Joachim
中科院分区：
文献类型：
--
作者：
Gerlach, Debora;Kaminski, Tim;Kappler, Joachim
脑的细胞外基质是高度组织化的基于透明质酸的超分子组装体，其参与神经元寻路、细胞迁移、突触发生和神经元可塑性。在这里，我们分析了少突胶质前体细胞系的透明质酸丰富的细胞周围基质的结构，使用氦离子束扫描显微镜在亚纳米分辨率。我们发现薄的纳米纤维是这种少突胶质细胞周围基质的最终构建元素。这些结构可能参与调节少突胶质细胞的成熟和运动。(C)2010 Elsevier B.V.保留所有权利。
The extracellular matrix of the brain is a highly organized hyaluronan-based supramolecular assembly that is involved in neuronal pathfinding, cell migration, synaptogenesis and neuronal plasticity. Here, we analyze the structure of the hyaluronan-rich pericellular matrix of an oligodendroglial precursor cell line using helium ion beam scanning microscopy at a subnanometer resolution. We find that thin nanofibers are the ultimate building elements of this oligodendroglial pericellular matrix. These structures may participate in the regulation of oligodendroglial maturation and motility. (C) 2010 Elsevier B.V. All rights reserved.