THE CONCENTRATION OF OXYGEN DISSOLVED IN TISSUES AT THE TIME OF IRRADIATION AS A FACTOR IN RADIOTHERAPY
THE CONCENTRATION OF OXYGEN DISSOLVED IN TISSUES AT THE TIME OF IRRADIATION AS A FACTOR IN RADIOTHERAPY
复制标题
DOI：
10.1259/0007-1285-26-312-638
复制
发表时间：
1953-01-01
影响因子：
2.6
通讯作者：
SCOTT, OCA
中科院分区：
文献类型：
--
作者：
GRAY, LH;CONGER, AD;SCOTT, OCA
体外培养的埃利希小鼠腹水肿瘤细胞对x射线的放射敏感性在充氧条件下比在缺氧条件下高约3倍。对快中子的敏感度只与氧气压力有轻微的关系。在体内，当小鼠吸入纯氧时暴露在x射线下，实体瘤比吸入空气时表现出更大的消退。暴露于x射线下的小鸡成纤维细胞的细胞变性随着氧气压力的增加而增加。以Fe(NH4)2(SO4)2的形式照射在0.8[图像]硫酸中，Fe++的氧化表现出同样的对O2浓度的依赖。作为生物反应。然而，H2O2的产生并没有显示出对O2浓度的平行依赖。
The radiosensitivity of Ehrlich mouse ascites tumor cells to X-rays in vitro is about 3 times greater in a well oxygenated than in an anoxic medium. Sensitivity to fast neutrons is only slightly dependent on O2 pressure. The solid tumor, in vivo, showed greater regression when exposed to X-rays while the mice were inhaling pure O2 than when they were inhaling air. Cell degeneration in chick fibroblasts exposed to X-rays increases with increasing O2 pressure. Oxidation of Fe++, irradiated as Fe(NH4)2(SO4)2 in 0.8 [image]sulfuric acid, shows the same dependence on O2 concn. as biological reactions. Production of H2O2 however, does not show such a parallel dependence on O2 concn.