Peripheral blood stem cell transplantation for hepatoblastoma with microscopical residue: A therapeutic approach for incompletely resected tumor
Peripheral blood stem cell transplantation for hepatoblastoma with microscopical residue: A therapeutic approach for incompletely resected tumor
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DOI：
10.1620/tjem.184.247
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发表时间：
1998-03-01
影响因子：
2.2
通讯作者：
Iinuma, K
中科院分区：
文献类型：
--
作者：
Yoshinari, M;Imaizumi, M;Iinuma, K
我们报告一个九个月大的男孩与第三阶段B肝母细胞瘤的尾状叶起源。经过六个疗程的化疗后，尝试手术切除，但显微镜下可见切除边缘仍有存活的肿瘤细胞。随后，他接受了外周血干细胞移植（PBSCT），其准备方案由卡铂、依托泊苷、四氢吡喃阿霉素和美法仑组成。此后，患者未显示局部复发或远处转移的相关性，未接受任何化疗。PBSCT治疗术后残留物可改善晚期肝母细胞瘤的预后，值得进一步临床研究。(C)1998年东北大学医学出版社。
We report a nine-month-old boy with stage III B hepatoblastoma of caudate lobe origin. Surgical resection was attempted following six courses of chemotherapy, but viable tumor cells remained microscopically at resection margins. Subsequently, he received peripheral blood stem cell transplantation (PBSCT), whose preparative regimen being consisted of carboplatin, etoposide, tetrahydropyranyl adriamycin, and melphalan. Since then, the patient shows no relevance of local relapse or distant metastasis without any chemotherapy. PBSCT for patients with post-operative residue may improve the outcome of advanced hepatoblastoma and worth of a further clinical investigation. (C) 1998 Tohoku University Medical Press.