Thyroid Cancer Incidence by Histological Type and Related Variants in a Mildly Iodine-Deficient Area of Northern Italy, 1998 to 2009
Thyroid Cancer Incidence by Histological Type and Related Variants in a Mildly Iodine-Deficient Area of Northern Italy, 1998 to 2009
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DOI：
10.1002/cncr.27591
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发表时间：
2012-11-15
期刊：
影响因子：
6.2
通讯作者：
Ceda, Gian Paolo
中科院分区：
文献类型：
--
作者：
Ceresini, Graziano;Corcione, Luigi;Ceda, Gian Paolo
背景：甲状腺癌的发病率在一些国家呈上升趋势。然而，这是否适用于所有不同的组织学类型和相关变异的问题还没有得到很好的解决。方法：1998年至2009年间在意大利北部轻度碘缺乏地区诊断的所有甲状腺癌事件均来自基于人群的肿瘤登记。从病理报告和载玻片的回顾中记录疾病的分期、肿瘤的大小、病灶和组织学变异。计算整个12年观察期标准化发病率的平均年增长率（MAI），并评估标准化发病率比，比较1998-2003年和2004-2009年两个时期（每个6年）的平均标准化发病率。结果：共纳入980例。所有甲状腺肿瘤的发病率均呈上升趋势；从1998年到2002年，这种增长是持续的，但之后就没有了。男性和女性的癌症发病率都有所增加。甲状腺乳头状癌（PTC）、滤泡型、高细胞型（TCV-PTC）和Hurthle细胞癌（HC）的发病率变化最为相关，而滤泡型癌的发病率变化不明显。TCV-PTC是唯一在第二个6年观察期间显示显著（P < 0.01）比例增加的组织学类型。2002年以后，只有TCV-PTC和HC出现了显著的MAI。结论：在过去十年中，甲状腺癌的发病率有所增加，这种增加主要是由分化肿瘤引起的。最显著的增加是基本组织型的侵袭性变异。2012年癌症。(C) 2012年美国癌症协会。
BACKGROUND: The incidence of thyroid cancer is increasing in several countries. However, the issue of whether this applies to all different histological types and related variants is poorly addressed. METHODS: All incident thyroid cancers diagnosed between 1998 and 2009 in a mildly iodine-deficient area in northern Italy were derived from a population-based tumor registry. Stage of disease, size of the tumor, focality, and histological variants were recorded from a review of pathology reports and slides. The mean annual increase (MAI) of the standardized incidence rate was calculated over the entire 12-year period of observation and a standardized rate ratio was evaluated to compare the mean standardized incidence between 2 periods of 6 years each (1998-2003 vs 2004-2009). RESULTS: In total, 980 cases were considered. An increase in the incidence trend for all thyroid tumors was demonstrated; the increase was found to be continuous from 1998 to 2002 but not afterward. The cancer incidence increased in both male and female subjects. Papillary thyroid carcinoma (PTC), the follicular variant of PTC, the tall cell variant of PTC (TCV-PTC), and Hurthle cell carcinoma (HC) showed the most relevant changes in incidence whereas follicular carcinoma was not found to be significantly affected. TCV-PTC was the only histological type to demonstrated a significant (P < .01) proportional increase in the second 6-year period of observation. Only TCV-PTC and HC were found to display a significant MAI after 2002. CONCLUSIONS: The incidence of thyroid cancer has increased within the last decade, an increase that is accounted for mostly by differentiated tumors. The most significant increases were documented for aggressive variants of basic histotypes. Cancer 2012. (C) 2012 American Cancer Society.