Physical activity, body size and composition, and risk of ovarian cancer
Physical activity, body size and composition, and risk of ovarian cancer
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DOI：
10.1007/s10552-010-9638-y
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发表时间：
2010-12-01
影响因子：
2.3
通讯作者：
Giles, Graham G.
中科院分区：
文献类型：
--
作者：
Chionh, Fiona;Baglietto, Laura;Giles, Graham G.
目的 我们在墨尔本合作队列研究中研究了卵巢癌风险与体力活动和人体测量（体重指数、身高、腰围、脂肪和去脂体重）之间的关联。方法这项前瞻性队列研究纳入了 1990 年至 1994 年间招募的 18,700 名 26-76 岁女性。参与者接受了有关体力活动的采访，包括频率和强度。直接测量身体尺寸；通过生物电阻抗分析计算脂肪量和去脂量。在平均 10.2 年的随访中，确诊了 113 例卵巢癌。采用Cox回归估计风险比。结果调整潜在混杂因素后，与无体力活动相比，总体力活动水平的风险比为低水平1.56（95% CI：0.81，3.00），中水平1.92（1.07，3.45），高水平2.21（1.16，4.24）（趋势检验，p = 0.01）。与 BMI 相关的卵巢癌风险比为每 5 kg/m(2) 增量 1.22（95% CI：1.00, 1.48；p 趋势，0.06），脂肪量每 10 kg 增量为 1.23（95% CI：1.01, 1.49；p 趋势，0.04）。较高水平的体力活动和体型增加会增加患卵巢癌的风险。
Objectives We examined the association between risk of ovarian cancer and physical activity and anthropometry (body mass index, height, waist, fat, and fat-free mass) in the Melbourne Collaborative Cohort Study.Methods This prospective cohort study included 18,700 women aged 26-76 years old at recruitment between 1990 and 1994. Participants were interviewed about their physical activity, including frequency and intensity. Body measurements were taken directly; fat mass and fat-free mass were calculated from bioelectrical impedance analysis. During an average of 10.2 years of follow-up, 113 ovarian cancers were ascertained. Cox regression was used to estimate hazard ratios.Results After adjusting for potential confounders, compared with no physical activity, the hazard ratios for levels of total physical activity were 1.56 (95% CI: 0.81, 3.00) for low level, 1.92 (1.07, 3.45) for medium level, and 2.21 (1.16, 4.24) for high level (test for trend, p = 0.01). The hazard ratio for ovarian cancer in relation to BMI was 1.22 (95% CI: 1.00, 1.48; p-trend, 0.06) per 5 kg/m(2) increment, and for fat mass, 1.23 ( 95% CI: 1.01, 1.49; p-trend, 0.04) per 10 kg increment.Conclusions This study found some evidence for a possible relationship between higher levels of physical activity and body size and increased ovarian cancer risk.