Acute physical exercise in humans enhances reconsolidation of emotional memories
Acute physical exercise in humans enhances reconsolidation of emotional memories
复制标题
DOI：
10.1016/j.psyneuen.2017.09.019
复制
发表时间：
2017-12-01
影响因子：
3.7
通讯作者：
Bryant, Richard A.
中科院分区：
文献类型：
--
作者：
Keyan, Dharani;Bryant, Richard A.
越来越多的证据表明，当记忆通过提取被重新激活时，它会暂时容易受到环境或药物操纵的影响，从而更新或加强记忆。体育锻炼已被证明可以调节动物在记忆重新激活后对恐惧记忆的维持。本研究探讨了剧烈运动对创伤记忆再巩固的调节作用。54名本科生观看了一部描述高速公路车祸后果的创伤电影。两天后，参与者进行（a）记忆重新激活诱导（重新激活/运动）后20-25分钟的增量骑自行车，（b）记忆重新激活后20-25分钟的轻度骑自行车（重新激活/无运动），或（B）20 - 25分钟的增量骑自行车（重新激活/无运动）记忆重新激活，或（c）20-25分钟的增量骑自行车但无记忆重新激活（无重新激活/运动）。收集唾液样本以在基线和活动后对唾液淀粉酶和皮质醇进行指数化。参与者在记忆激活后两天完成了与陈述性和侵入性记忆回忆有关的记忆问卷。相对于其他参与者，重新激活/运动参与者回忆起创伤电影的更多核心细节。皮质醇的增加预示着在再激活/运动中更好的总记忆回忆，但在其他条件下则不然。这些发现表明，在记忆再激活期间的剧烈运动增强了随后的创伤记忆，并提供了与最近在动物中发现的运动诱导的恐惧再巩固相一致的人类证据。
Increasing evidence suggests that when a memory is reactivated through retrieval, it becomes temporarily vulnerable to environmental or pharmacological manipulation, which can consequently update or strengthen the memory. Physical exercise has been shown to modulate the maintenance of fear memories in animals following memory reactivation. This study investigated the effect of intense exercise in modulating the reconsolidation of trauma memories. Fifty-four undergraduate students watched a trauma film depicting the aftermath of a highway car crash. Two days later, participants engaged in either (a) 20-25 min of incremental cycling following a memory reactivation induction (Reactivation/Exercise), (b) 20-25 min of mild cycling (Reactivation/No Exercise) following memory reactivation, or (c) 20-25 min of incremental cycling but no memory reactivation (No Reactivation/Exercise). Saliva samples were collected to index salivary amylase and cortisol at baseline and post activity. Participants completed memory questionnaires relating to declarative and intrusive memory recall two days after memory reactivation. Reactivation/Exercise participants recalled more central details of the trauma film relative to other participants. Increased cortisol predicted better total memory recall in the Reactivation/Exercise, but not in the other conditions. These findings suggest that intense exercise during the period of memory reactivation enhances subsequent trauma memory, and provides human evidence consistent with recent findings of exercise-induced fear reconsolidation in animals.