The stress hormone corticosterone conditions AMPAR surface trafficking and synaptic potentiation
The stress hormone corticosterone conditions AMPAR surface trafficking and synaptic potentiation
复制标题
DOI：
10.1038/nn.2150
复制
发表时间：
2008-08-01
影响因子：
25
通讯作者：
Chaouloff, Francis
中科院分区：
文献类型：
--
作者：
Groc, Laurent;Choquet, Daniel;Chaouloff, Francis
皮质酮促进了海马谷氨酸的传递，但AMPA受体(AMPAR)信号调节的细胞通路仍不清楚。活体大鼠海马神经元的单量子点成像显示，皮质酮通过不同的皮质类固醇受体触发GluR2-AMPAR表面迁移率和突触表面GluR2含量的时间依赖性增加。此外，皮质酮通过化学长时程增强刺激增强突触表面GluR2含量的增加，揭示了皮质酮对AMPAR转运的影响。
Corticosterone facilitates hippocampal glutamate transmission, but the cellular pathways by which AMPA receptor (AMPAR) signaling is adjusted remain elusive. Single quantum-dot imaging in live rat hippocampal neurons revealed that corticosterone triggers, via distinct corticosteroid receptors, time-dependent increases in GluR2-AMPAR surface mobility and synaptic surface GluR2 content. Furthermore, corticosterone potentiates the increase of synaptic surface GluR2 contents by a chemical long-term potentiation stimulus, revealing the influence that corticosterone has on AMPAR trafficking.