Repetitive transcranial magnetic stimulation in the treatment of obsessive-compulsive disorders: Double blind randomized clinical trial
Repetitive transcranial magnetic stimulation in the treatment of obsessive-compulsive disorders: Double blind randomized clinical trial
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DOI：
10.1016/j.psychres.2016.02.031
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发表时间：
2016-04-30
影响因子：
11.3
通讯作者：
Khedr, Eman M.
中科院分区：
文献类型：
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作者：
Elbeh, Khaled A. M.;Elserogy, Yasser M. B.;Khedr, Eman M.
重复经颅磁刺激（rTMS）已被广泛用作精神病学研究的治疗工具。本研究的目的是评估不同频率的rTMS对强迫症患者右背外侧前额叶皮层（DLPFC）的影响。45名强迫症患者参加了这项研究。使用以下指标评价患者：Yale-Brown强迫量表（Y-BOCS）、汉密尔顿焦虑量表（HAM-A）和临床疗效总评量表（CGI-S）。将他们随机分为三组：第一组接受1 Hz rTMS;第二组接受10 Hz rTMS;第三组接受100%静息运动阈值的假刺激，共10次。在末次治疗后和3个月后随访。对于1 Hz与假手术，存在显著的“时间”x“组”相互作用，但对于10 Hz与假手术，不存在显著的“时间”x“组”相互作用。1 Hz与10 Hz组显示Y-BOCS和HAM-A的显著相互作用（分别为P=0.001和0.0001）。1 Hz rTMS的临床受益大于10 Hz或假手术。与10 Hz或假手术组相比，1 Hz组的GCI-S百分比变化也显著更大。我们的结论是，1赫兹rTMS，针对右DLPFC是一个有前途的工具，用于治疗强迫症。(C)2016爱思唯尔爱尔兰有限公司版权所有。
Repetitive transcranial magnetic stimulation (rTMS) has become widely used as a therapeutic tool in psychiatric research. The aim of this study was to evaluate the impact of different frequencies of rTMS over right dorsolateral prefrontal cortex (DLPFC) in OCD. Forty five patients with OCD participated in the study. Patients were evaluated using: Yale-Brown obsessive compulsive scale (Y-BOCS), Hamilton Anxiety Rating Scale (HAM-A), and Clinical Global Impression-Severity scale (CGI-S). They were randomly classified into three groups: 1st group received 1 Hz rTMS; 2nd group received 10 Hz rTMS; and 3rd group received sham stimulation all at 100% of the resting motor threshold for 10 sessions. They were followed up after the last treatment session and 3 months later. There was a significant "time" x "group" interaction for 1 Hz versus Sham but not for 10 Hz versus Sham. 1 Hz versus 10 Hz groups showed a significant interaction for Y-BOCS and HAM-A (P=0.001 and 0.0001 respectively). 1 Hz rTMS has a greater clinical benefit than 10 Hz or Sham. There was also a significantly larger percentage change in GCI-S in the 1 Hz group versus either 10 Hz or sham. We conclude that 1 Hz-rTMS, targeting right DLPFC is a promising tool for treatment of OCD. (C) 2016 Elsevier Ireland Ltd. All rights reserved.