Differential contributions of dorsolateral and frontopolar cortices to working memory processes in the primate.
Differential contributions of dorsolateral and frontopolar cortices to working memory processes in the primate.
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DOI：
10.3389/fnsys.2015.00144
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发表时间：
2015
影响因子：
3
通讯作者：
Buckley MJ
中科院分区：
文献类型：
--
作者：
Boschin EA;Buckley MJ
跨越时间延迟保持和操纵信息的能力是弥合感知和行动之间差距的基本要求。在高阶行为的情况下，规则和策略的维护特别有助于弥合这一差距。长期以来，前额叶皮层（PFC）一直被认为对这些过程至关重要，研究集中在PFC的不同细分领域，以深入了解它们对这些机制的不同贡献。大量证据表明，背外侧PFC（dlPFC）是一个重要的结构，用于维持信息的延迟，与细胞积极发射的延迟和病变，这一地区造成赤字的任务，涉及延迟响应和维护的规则在线。另一方面，额极皮质（FP）似乎显示出相反的结果模式，细胞不发射跨越延迟和损伤，该区域不影响相同的基于规则的延迟反应任务，这些任务在dlPFC损伤后受损。因此，大量的证据表明，dlPFC和FP的工作记忆的贡献不同。在这篇文章中，我们将提供一个视角，这些区域如何实现不同但互补和交互的功能，有助于更一般的时间扩展过程，并支持灵活的，动态的行为。
The ability to maintain and manipulate information across temporal delays is a fundamental requirement to bridge the gap between perception and action. In the case of higher-order behavior, the maintenance of rules and strategies is particularly helpful in bridging this gap. The prefrontal cortex (PFC) has long been considered critical for such processes, and research has focused on different subdivisions of PFC to gain an insight into their diverse contributions to these mechanisms. Substantial evidence indicates that dorsolateral PFC (dlPFC) is an important structure for maintaining information across delays, with cells actively firing across delays and lesions to this region causing deficits in tasks involving delayed responses and maintenance of rules online. Frontopolar cortex (FP), on the other hand, appears to show the opposite pattern of results, with cells not firing across delays and lesions to this region not affecting the same rule-based, delayed response tasks that are impaired following dlPFC lesions. The body of evidence therefore suggests that dlPFC and FP’s contributions to working memory differ. In this article, we will provide a perspective on how these regions might implement distinct but complementary and interactive functions that contribute to more general temporally-extended processes and support flexible, dynamic behavior.