The callipyge phenomenon: evidence for unusual genetic inheritance.
The callipyge phenomenon: evidence for unusual genetic inheritance.
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卡利皮吉现象：异常遗传的证据。
DOI：
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发表时间：
1999
影响因子：
3.3
通讯作者：
M. Georges
中科院分区：
文献类型：
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作者：
N. Cockett;S. Jackson;G. Snowder;T. Shay;S. Berghmans;J. Beever;C. Carpenter;M. Georges
1983年，俄克拉荷马州多塞特郡的一个商业羊群中出生了一只雄性羔羊，它表现出明显的肌肉肥大，尤其是在后腿。这只公羊最初被称为纯金。随后，他产生了表达这种不寻常表型的后代，这种表型被称为callipyge（希腊语：愈伤组织-美丽+ -pyge臀部）。这些动物都是这只公羊的后代。这些动物的胴体更瘦，产量更高，但腰部的柔嫩程度有所下降。基因座的遗传特征证明了一种称为极显性的独特遗传模式，其中只有杂合后代继承了来自其父亲的突变表达表型。其他三种基因型在外观上是正常的。后代数据表明，母系callipyge等位基因在通过雄性生殖系后发生再激活，尽管这种再激活不是绝对的。callipyge基因被定位在羊18号染色体的远端。
In 1983, a male lamb exhibiting a pronounced muscular hypertrophy, particularly noticeable in the hind quarters, was born into a commercial Dorset flock in Oklahoma. The ram was premonitorily called Solid Gold. He subsequently produced offspring expressing the unusual phenotype, which is referred to as callipyge (Greek: calli- beautiful + -pyge buttocks). Animals demonstrating the callipyge phenotype are all descendants of this founder ram. These animals produce leaner, higher yielding carcasses, but there is some concern with decreased tenderness of the loin. Genetic characterization of the locus has demonstrated a unique mode of inheritance termed polar overdominance, in which only heterozygous offspring inheriting the mutation from their sire express the phenotype. The three other genotypes are normal in appearance. Progeny data indicate that reactivation of the maternal callipyge allele occurs after passage through the male germ line, although this reactivation is not absolute. The callipyge gene has been mapped to the distal end of ovine chromosome 18.