Stat3 activation is required for cellular transformation by v-src
Stat3 activation is required for cellular transformation by v-src
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DOI：
10.1128/mcb.18.5.2553
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发表时间：
1998-05-01
影响因子：
5.3
通讯作者：
Darnell, JE
中科院分区：
文献类型：
--
作者：
Bromberg, JF;Horvath, CM;Darnell, JE
Stat 3激活与精氨酸诱导的增殖、抗凋亡和转化相关。组成型活化的Stat 3已在许多人类肿瘤以及v-abl-和v-src-转化的细胞系中发现。由于这些相关性，我们直接检查了激活的Stat 3与细胞转化的关系，发现野生型Stat 3增强了v-src的转化潜力，而三种显性负性Stat 3突变体抑制v-src转化。Stat 3野生型或突变蛋白不影响v-ras转化。我们的结论是，Stat 3有一个必要的作用，在v-src转换。
Stat3 activation has been associated with cytokine-induced proliferation, anti-apoptosis, and transformation. Constitutively activated Stat3 has been found in many human tumors as well as v-abl- and v-src-transformed cell lines. Because of these correlations, we examined directly the relationship of activated Stat3 to cellular transformation and found that wild-type Stat3 enhances the transforming potential of v-src while three dominant negative Stat3 mutants inhibit v-src transformation. Stat3 wild-type or mutant proteins did not affect v-ras transformation. We conclude that Stat3 has a necessary role in v-src transformation.