The associations between socioeconomic status and risk of Staphylococcus aureus bacteremia and subsequent endocarditis - a Danish nationwide cohort study.
The associations between socioeconomic status and risk of Staphylococcus aureus bacteremia and subsequent endocarditis - a Danish nationwide cohort study.
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社会经济地位与金黄色葡萄球菌菌血症的风险与随后的心内膜炎之间的关联 - 丹麦全国人群研究。
DOI：
10.1186/s12879-017-2691-3
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发表时间：
2017-08-25
影响因子：
3.7
通讯作者：
Torp-Pedersen C
中科院分区：
文献类型：
--
作者：
Oestergaard LB;Schmiegelow MD;Bruun NE;Skov RL;Petersen A;Andersen PS;Torp-Pedersen C
金黄色葡萄球菌菌血症(SAB)是几个国家感染性心内膜炎的主要原因。由于社会经济地位(SES)通常影响感染疾病的风险，我们的目的是在全国成年人中调查SES和SAB之间的关系，以及随后发生心内膜炎的风险。在1996年至2010年期间，所有丹麦居民的年龄都连续包括在30岁以下的≥。我们通过交叉链接全国登记，获得了关于SES(最高教育水平)、合并症和微生物验证的SAB的信息。SAB和后来的心内膜炎的发生率比(IRR)用泊松回归模型进行了研究，这些模型调整了性别、年龄和年份(参考数据=最高的SES)。我们的研究人群包括3,394,936人(中位年龄=1，43.2岁)。在15.9年的中位数随访中，13,181人感染了SAB。社会保障与社会保障的获得呈负相关，社会保障水平最低的个体，30-50岁的内部收益率为3.78(95%可信区间=2.89-4.95)，50-70岁的内部收益率为1.87(95%可信区间=1.60-2.18)，70岁的内部收益率为1.31(可信区间为1.11-1.54)。对合并症的调整减弱了IRR，但这种模式仍然存在。在SAB患者中，未观察到SES与心内膜炎风险之间的关联。SES降低与SAB风险增加相关，尤其是在年轻人中。SES与随后发生心内膜炎的风险无关。本文的在线版本(doi：10.1186/s12879-0172691-3)包含补充材料，授权用户可以使用。
Staphylococcus aureus bacteremia (SAB) is the leading cause of infective endocarditis in several countries. Since socioeconomic status (SES) is known to influence the risk of infectious diseases in general, we aimed to investigate the association between SES and SAB, and risk of subsequent endocarditis in a nationwide adult population. All Danish residents were consecutively included at age ≥ 30 years during 1996–2010. We obtained information on SES (highest attained educational level), comorbidities, and microbiologically verified SAB by cross-linking nationwide registries. The incidence rate ratios (IRRs) of SAB and later endocarditis were investigated using Poisson regression models adjusted for sex, age and year (reference = highest SES). Our study population comprised 3,394,936 individuals (median age = 43.2 years). Over a median follow-up of 15.9 years, 13,181 individuals acquired SAB. SES was inversely associated with SAB acquisition, which declined with increasing age, e.g. in individuals with lowest SES, IRRs were 3.78 (95% confidence interval [CI] = 2.89–4.95) in age 30–50 years, 1.87 (CI = 1.60–2.18) in age > 50–70 years and 1.31 (CI = 1.11–1.54) in age > 70 years (interaction-p < 0.0001). Adjustment for comorbidities attenuated the IRRs, but the pattern persisted. No association between SES and endocarditis risk among patients with SAB was observed. Decreasing SES was associated with an increased risk of SAB, particularly in younger adults. SES was not associated with risk of subsequent endocarditis. The online version of this article (doi:10.1186/s12879-017-2691-3) contains supplementary material, which is available to authorized users.
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影响因子：
28.2
作者：
Kaasch, Achim J.;Barlow, Gavin;Edgeworth, Jonathan D.;Fowler, Vance G.;Hellmich, Martin;Hopkins, Susan;Kern, Winfried V.;Llewelyn, Martin J.;Rieg, Siegbert;Rodriguez-Bano, Jesus;Scarborough, Matthew;Seifert, Harald;Soriano, Alex;Tilley, Robert;Torok, M. Estee;Weiss, Verena;Wilson, A. Peter R.;Thwaites, Guy E.
通讯作者：
Thwaites, Guy E.
影响因子：
3.7
作者：
Le Moing, Vincent;Alla, Francois;Duval, Xavier
通讯作者：
Duval, Xavier
对心房颤动患者预测中风和血栓栓塞的风险分层方案的验证：全国同伴研究。
DOI：
10.1136/bmj.d124
发表时间：
2011-01-31
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Olesen JB;Lip GY;Hansen ML;Hansen PR;Tolstrup JS;Lindhardsen J;Selmer C;Ahlehoff O;Olsen AM;Gislason GH;Torp-Pedersen C
通讯作者：
Torp-Pedersen C
影响因子：
3.4
作者：
Jensen, Vibeke M.;Rasmussen, Astrid W.
通讯作者：
Rasmussen, Astrid W.
影响因子：
5
作者：
Koch, Kristoffer;Sogaard, Mette;Schonheyder, Henrik Carl
通讯作者：
Schonheyder, Henrik Carl