Tissue-specific bioenergetic effects and increased enzymatic activities following acute sublethal peroral exposure to cyanide in the mallard duck.
Tissue-specific bioenergetic effects and increased enzymatic activities following acute sublethal peroral exposure to cyanide in the mallard duck.
复制标题
野鸭急性亚致死口服氰化物后的组织特异性生物能效应和酶活性增加。
DOI：
10.1006/taap.1996.8045
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Pritsos,CA
中科院分区：
文献类型：
--
作者：
Ma,J;Pritsos,CA
保护野生动物，特别是受《候鸟条约法》保护的候鸟，使其免受金矿开采作业中和周围氰化物废物的影响，是一个重要的环境问题。我们已经调查了亚致死经口氰化物暴露的生物能量效应的绿头鸭（Anus platyrhynchos）作为模式候鸟。在氰化物浓度远低于采矿业和一些监管机构认为安全的水平（50 ppm弱酸可解离（WAD）氰化物）时，观察到心脏、肝脏和脑组织ATP水平的显著消耗。组织ATP水平恢复到正常的24小时后exxatively。Rhodanese和3-巯基丙酮酸硫转移酶的活动进行了测定，在这些组织的基础活动和氰化物暴露后。只有脑组织表现出增加酶活性氰化物暴露后，这些酶活性的组织特异性调节。这些研究表明，50 ppm的WAD氰化物不是水中氰化物的安全水平，鸟类野生动物可能会接触到氰化物。
Protection of wildlife and in particular migratory birds, which are protected by the Migratory Bird Treaty Act, from cyanide waste in and around gold mining operations is an important environmental issue. We have investigated the bioenergetic effects of sublethal peroral cyanide exposure using the mallard duck (Anus platyrhynchos) as a model migratory bird. At cyanide concentrations well below levels considered safe by the mining industry and some regulatory agencies (50 ppm weak acid dissociable (WAD) cyanide) significant depletions of heart, liver, and brain tissue ATP levels were observed. Tissue ATP levels were restored to normal by 24 hr postexposure. Rhodanese and 3-mercaptopyruvate sulfurtransferase activities were determined in these tissues both for basal activity and post-cyanide exposure. Only brain tissue showed increased enzymatic activity following cyanide exposure, suggesting tissue-specific regulation of these enzymatic activities. These studies suggest that 50 ppm WAD cyanide is not a safe level of cyanide in water where avian wildlife exposure can occur.