THE RELATIVE CONTRIBUTION OF THE NERVOUS-SYSTEM, HORMONES, AND METABOLITES TO THE TOTAL INSULIN-RESPONSE DURING A MEAL IN THE RAT
THE RELATIVE CONTRIBUTION OF THE NERVOUS-SYSTEM, HORMONES, AND METABOLITES TO THE TOTAL INSULIN-RESPONSE DURING A MEAL IN THE RAT
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DOI：
10.1016/0026-0495(84)90157-4
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发表时间：
1984-01-01
影响因子：
9.8
通讯作者：
BERTHOUD, HR
中科院分区：
文献类型：
--
作者：
BERTHOUD, HR
尝试定量测定清醒自由活动大鼠在10分钟液体餐期间神经系统、激素因子和代谢产物对总外周血浆胰岛素反应（积分增量面积）的相对贡献。神经介导的胰岛素反应，在胃瘘轴承假喂养大鼠，至少达26%。然而，尚未确定由膳食的胃、肠和吸收后阶段触发的神经机制的可能贡献。基于对阿托品化大鼠中真实的喂养的胰岛素反应，在没有任何血浆葡萄糖增加和血浆α-葡萄糖仅少量升高的情况下，发现激素因子对总胰岛素反应贡献至少30%。氨基氮未分离出可能的阿托品抑制激素因子。最后，发现通过静脉输注葡萄糖测定的血糖升高的相对贡献不超过20%;然而，未测定血浆氨基酸升高的贡献。在总的胰岛素反应中，23%不能被分离，但认为其中很大一部分可以归因于协同机制。由于这种相互作用，孤立因素的影响之和小于组合因素的影响。
An attempt was made to quantitatively determine the relative contribution of the nervous system, hormonal factors and metabolites to the total peripheral plasma insulin response (integrated incremental area) during a 10 min liquid meal in conscious freely moving rats. The neurally-mediated insulin response, as measured in the gastric-fistula bearing sham-feeding rat, amounted to at least 26%. The possible contribution of neural mechanisms triggered by the gastric, intestinal and postabsorptive phases of the meal were, however, not determined. Hormonal factors were found to contribute at least 30% to the total insulin response on the basis of the insulin response to real feeding in atropinized rats, in the absence of any increases of plasma glucose and with only small elevations of plasma .alpha.-amino nitrogen. A possible atropine-suppressible hormonal factor was not isolated. Finally, the relative contribution of rising plasma glucose as determined by i.v. glucose infusions was found to amount to no more than 20%; however, the contribution of rising plasma amino acids was not determined. Of the total insulin responses, 23% could not be segregated, but it is thought that a good part of it can be attributed to synergistic mechanisms. Because of such interactions, the sum of the effects of the isolated factors is less than the effect of the combined factors.