Functional evaluation indicates physical losses after hematopoietic stem cell transplantation
Functional evaluation indicates physical losses after hematopoietic stem cell transplantation
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DOI：
10.5581/1516-8484.20120090
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发表时间：
2012-01-01
影响因子：
--
通讯作者：
Vigorito, Afonso Celso
中科院分区：
文献类型：
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作者：
Souza, Clarissa Vasconcellos de;Miranda, Eliana Cristina Martins;Vigorito, Afonso Celso
目的：方法：2008年11月至2010年11月，29例女性（58%）和21例男性（42%）患者入组本研究，年龄24-67岁，中位年龄48岁。在自体或异基因造血干细胞移植前后进行数据收集。评估工具包括2分钟步行试验以评估步态表现，评估试验前后的氧饱和度、心率和博格量表，握力用于评估力量，斯科贝尔试验用于测试脊柱活动度，最大和适应活动评分用于测试日常活动的功能。6人没有接受造血干细胞移植（3人死亡，1人拒绝，2人被排除）。因此，进行了44/50（88%-21例同种异体和23例自体）移植。44例患者中只有33例（75%）在移植后进行了评估（9例死亡，2例被排除）。在进行两项评估的患者中，发现移植后2分钟步行试验（p值= 0.004）、左右手握力（分别为p值= 0.004和p值<0.0001）、斯科贝尔测试以及最大和适应活动评分（p值<0.0001）的评估值显著较低。心率较高（p值= 0.01）前2分钟步行试验和血氧饱和度较高（p值= 0.02）后。结论：统计学差异表明移植后功能障碍，表现出身体的损失，在这个人口。
OBJECTIVE: To perform a function evaluation of patients before and after hematopoietic stem cell transplantation.METHODS: From November 2008 to November 2010, 29 female (58%) and 21 male patients (42%) with median age of 48 years (range: 24-67) were enrolled in this study. Data collection was performed before and after autologous or allogeneic hematopoietic stem cell transplantation. Evaluation instruments included the 2-minute walking test to evaluate gait performance with assessment of the oxygen saturation, heart rate and Borg Scale before and after the test; grip strength for strength evaluation, Schober Test for spine mobility testing and maximum and adapted activity scores of the Human Activity Profile questionnaire to test functionality in daily activities.RESULTS: Fifty patients were evaluated at baseline; six did not undergo hematopoietic stem cell transplantation (three died, one refused and two were excluded). Thus 44/50 (88% - 21 allogeneic and 23 autologous) transplantations were performed. Only 33 of the 44 patients (75%) performed evaluations after transplantation (nine died and two were excluded). Of the patients who performed both evaluations, significantly lower values were found in the evaluation after transplantation for the 2-minute walking test (p-value = 0.004), grip strength of both right and left hands (p-value = 0.004 and p-value < 0.0001, respectively), the Schober Test, and maximum and adapted activity scores (p-value < 0.0001). The heart rate was higher (p-value = 0.01) before the 2-minute walking test and oxygen saturation was higher (p-value = 0.02) after.CONCLUSION: Statistical differences indicate functional impairment after transplantation showing physical losses in this population.