The Domestic Ferret (Mustela putorius furo) as a Lethal Infection Model for 3 Species of Ebolavirus.
The Domestic Ferret (Mustela putorius furo) as a Lethal Infection Model for 3 Species of Ebolavirus.
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DOI：
10.1093/infdis/jiw209
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发表时间：
2016-08-15
期刊：
影响因子：
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通讯作者：
Geisbert TW
中科院分区：
文献类型：
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作者：
Cross RW;Mire CE;Borisevich V;Geisbert JB;Fenton KA;Geisbert TW
小动物模型已经开发了几个丝状病毒科物种，但是，需要一系列的适应，以产生致命的感染。这些适应性病毒在几个基因中有序列变化，包括那些调节宿主免疫反应的基因。非人灵长类动物模型不需要适应丝状病毒。在这里，我们描述了国内雪貂，使用野生型非适应病毒的本迪布焦，苏丹和扎伊尔种埃博拉病毒的致死性疾病模型。病理特征与灵长类动物的疾病一致。特别重要的是，这是为本迪布焦开发的唯一已知的小动物模型，也是本迪布焦唯一一致致死的动物模型。
Small-animal models have been developed for several Filoviridae species; however, serial adaptation was required to produce lethal infection. These adapted viruses have sequence changes in several genes, including those that modulate the host immune response. Nonhuman primate models do not require adaptation of filoviruses. Here, we describe lethal models of disease for Bundibugyo, Sudan, and Zaire species of Ebolavirus in the domestic ferret, using wild-type nonadapted viruses. Pathologic features were consistent with disease in primates. Of particular importance, this is the only known small-animal model developed for Bundibugyo and the only uniformly lethal animal model for Bundibugyo.