TROP2 expression and its correlation with tumor proliferation and angiogenesis in human gliomas
TROP2 expression and its correlation with tumor proliferation and angiogenesis in human gliomas
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DOI：
10.1007/s10072-013-1326-8
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发表时间：
2013-10-01
影响因子：
3.3
通讯作者：
Xin, Tao
中科院分区：
文献类型：
--
作者：
Ning, Shanglei;Liang, Nan;Xin, Tao
滋养层细胞表面抗原2（TROP2）是一种跨膜糖蛋白，与多种上皮癌的发生和进展相关，但其在胶质瘤中的表达和作用尚未被考虑。该研究的目的是探讨不同世界卫生组织（WHO）分类的恶性胶质瘤中TROP2的表达及其与肿瘤增殖和血管生成的相关性。采用免疫组织化学方法检测69例胶质瘤患者肿瘤标本和正常脑组织中TROP2和Ki-67的表达及微血管密度（MVD），并探讨TROP2和Ki-67与MVD之间的关系。免疫组化结果显示，69例肿瘤标本中有59例（85.5%）有TROP2表达，而正常脑组织中无表达。此外，TROP2 表达在 WHO III 级（P = 0.025）和 WHO IV 级（P = 0.011）神经胶质瘤中显着高于 WHO II 级神经胶质瘤。在人类神经胶质瘤中，TROP2 表达与 Ki-67（r = 0.676，P = 0.012）和 MVD（r = 0.365，P = 0.035）相关，但与性别或年龄无关。这些结果表明TROP2与人类神经胶质瘤的恶性、增殖和血管生成相关。这是第一项描述神经胶质瘤中 TROP2 表达的研究，其增殖和血管生成相关特征可能作为神经胶质瘤治疗的潜在治疗靶点。
Trophoblast cell surface antigen 2 (TROP2) is a transmembrane glycoprotein which is associated with tumor development and progression in a variety of epithelial carcinomas, while its expression and role in gliomas have not been considered. The aim of the study was to investigate TROP2 expression in malignant gliomas with different World Health Organization (WHO) classification and its correlation with tumor proliferation and angiogenesis. Immuohistochemistry was used to determine TROP2 and Ki-67 expression and microvessel density (MVD) in tumor specimens and normal brain tissues from 69 glioma patients and the relationship between TROP2 and Ki-67 and MVD was investigated. Immunohistochemistry results showed that the TROP2 expression was found in 59 (85.5 %) of the 69 tumor specimens, but no expression in normal brain tissues. Furthermore, TROP2 expression is significantly higher in WHO grade III (P = 0.025) and WHO grade IV (P = 0.011) gliomas than in WHO grade II gliomas. TROP2 expression correlates with Ki-67 (r = 0.676, P = 0.012) and MVD (r = 0.365, P = 0.035), but not with gender or age in human gliomas. These results suggested that the TROP2 correlated with malignancy, proliferation and angiogenesis in human gliomas. This is the first study describing TROP2 expression in gliomas and its proliferation and angiogenesis-related characteristic may serve as a potential therapeutic target for glioma treatment.