Working memory in siblings of schizophrenia patients
Working memory in siblings of schizophrenia patients
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DOI：
10.1016/j.schres.2007.06.020
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发表时间：
2007-09-01
影响因子：
4.5
通讯作者：
Fananas, Lourdes
中科院分区：
文献类型：
--
作者：
Barrantes-Vidal, Neus;Aguilera, Mari;Fananas, Lourdes
工作记忆（WM）几乎没有探讨精神分裂症患者的非精神病亲属，尽管其潜在的适合作为一种神经认知内表型。事实上，WM模式，组件和过程很少在同一组亲属进行比较。本研究探讨了精神分裂症患者的健康同胞的神经认知性能，包括空间和言语工作记忆模式和测试轻敲维持（空间跨度向后和CPT-IP d '）和操纵（字母和数字排序）工作记忆processes.Methods：68例精神分裂症患者，38名健康同胞和63名对照组进行了评估的智商，注意，记忆，工作记忆和执行功能。结果：在同胞和对照组中筛选出A群症状。他们的表现不如控制智商，LNS，动物命名，向后的空间跨度，语音流畅性，数字D '，和向前spatial span.Discussion：与WM文献精神分裂症，言语和空间WM兄弟姐妹和对照组之间的显着差异，这表明WM赤字是独立的方式。我们的研究结果未能支持这一假设，即测试挖掘WM操纵过程严重加载DLFPC定量受损的亲属，因此，更敏感的精神分裂症的责任。然而，确切的结论不能得出，直到更多的研究评估维护和操纵工作记忆过程中的亲属。(c)2007 Elsevier B. V.保留所有权利。
Working memory (WM) has hardly been explored in non-psychotic relatives of schizophrenic patients despite its potential suitability as a neurocognitive endophenotype. Indeed, WM modalities, components and processes have rarely been compared in the same group of relatives. The present study examined neurocognitive performance in healthy siblings of schizophrenic patients, including both spatial and verbal WM modalities and tests tapping maintenance (Spatial Span Backwards and CPT-IP d') and manipulative (Letters and Numbers Sequencing) WM processes.Methods: 68 schizophrenia patients, 38 healthy siblings and 63 controls were assessed on IQ, attention, memory, WM, and executive functions. Cluster A symptoms were screened out in siblings and controls.Results: Siblings had an intermediate performance between that of schizophrenic patients and controls. They performed worse than controls on IQ, LNS, animal naming, backwards spatial span, phonemic fluency, numbers d', and forward spatial span.Discussion: Consistent with the WM literature in schizophrenia, both verbal and spatial WM differed significantly between siblings and controls, suggesting that WM deficits are modality independent. Our results failed to support the hypothesis that tests tapping WM manipulative processes heavily loading on DLFPC are quantitatively more impaired in relatives and, therefore, more sensitive to liability for schizophrenia. However, firm conclusions cannot be drawn until more studies assessing both maintenance and manipulative WM processes in relatives are available. (c) 2007 Elsevier B.V. All rights reserved.