The concept of fractals in the pharmaceutical sciences.
The concept of fractals in the pharmaceutical sciences.
复制标题
制药科学中的分形概念。
DOI：
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
Koch Hp
中科院分区：
文献类型：
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作者：
Koch Hp
与用经典方法反复研究相比，从新的角度来看待一个老问题有时会更好地理解它。这种新的视角是由分形学的概念提供的。简而言之，这个术语定义了几何形状的扩展类，其子单元根据自相似概念的形式化复制较大单元的结构。这一概念是由曼德尔-布罗特提出的，以回应对自然界中常见的许多现象进行更复杂解释的需要。在这篇综述中，我们将简要介绍分形学的概念，并简要概述到目前为止在药物研究中应用分形学的那些研究。我们相信，回顾在应用分形几何解决制药科学中遇到的问题方面的最新发现，也可能对那些参与寻找新药物物质以及研究其体外和体内性能的人有所帮助。在这个概念可能对未来有帮助的地方，将提出一些建议，并将就如何实用地估计崎岖物体的分维提供指导。
An old problem is sometimes better understood when it is viewed from a new perspective than by investigating it repeatedly with classical methods. Such a new perspective is provided by the concept of fractals. Briefly, this term defines a spread class of geometric shapes, whose subunits replicate the structure of the larger unit in accordance with the formalization of the idea of self-similarity. This concept was introduced by Mandel-brot in respond to the need for a more sophisticated explanation of numerous phenomena commonly encountered in nature. In this review we will provide a short introduction into the concept of fractals and a concise overview of those studies where fractal geometry has been employed so far in pharmaceutical research. We believe that a review of the most recent findings in the application of fractal geometry to problems encountered in the pharmaceutical sciences might be helpful also to those people who are involved in the search for novel drug substances, as well as in the investigation of their performance in vitro and in vivo. A few suggestions will be made where this concept probably could be helpful in the future and instructions will be given on how the fractal dimension of rugged objects can be estimated practically.