Fractionated simple and choice reaction time in children with prenatal exposure to alcohol.
Fractionated simple and choice reaction time in children with prenatal exposure to alcohol.
复制标题
产前接触酒精的儿童的分段简单反应时间和选择反应时间。
DOI：
10.1097/01.alc.0000030563.14827.29
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发表时间：
2002
期刊：
影响因子：
--
通讯作者：
Riley,EdwardP
中科院分区：
文献类型：
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作者：
Simmons,RogerW;Wass,Tara;Thomas,JenniferD;Riley,EdwardP
背景本研究采用简单反应时（SRT）和选择反应时（CRT）任务，对宫内接触酒精的儿童与对照组儿童的中枢和外周加工速度进行了比较。每个RT间隔被细分为运动前区和运动区，以分别评估刺激信息的中央处理和外周运动单位的募集。方法11名确诊产前酒精暴露（ALC）的儿童和13名对照受试者（NC），年龄为5至10岁，完成了20项SRT和CRT任务的试验。肌肉活动记录从肱二头肌肌肉的每一个手臂，使用肌电图，以方便RT到premotor和电机components.ResultsALC儿童的细分表现出显着较慢的运动前RT在CRT任务。在SRT和CRT任务中，ALC组的运动RT也较慢。与对照组相比，ALC儿童表现出更大的反应变异性;然而，考虑到他们延长的RT，这种变异性的大小并不大于预期。与此相反，反应变异性是更大的幼儿两组，即使占平均RT。显着的年龄相关的差异在运动前和运动RTs也observed.ConclusionsAlcohol-相关的增加CRT是由于较长的运动前和运动组件，反映了信息处理和周边延迟响应的速度降低。这些改变可能与中枢和外周神经系统中与酒精相关的变化有关，这些变化可能会阻碍或减缓神经元的传递。
BackgroundThe present study investigated central and peripheral processing speed using simple reaction time (SRT) and choice reaction time (CRT) tasks in children who were exposed to alcohol in utero compared with control subjects. Each RT interval was fractionated into premotor and motor components to assess the central processing of stimulus information and peripheral motor unit recruitment, respectively.MethodsEleven children with confirmed prenatal alcohol exposure (ALC) and 13 control subjects (NC), aged 5 to 10 years, completed 20 trials of both SRT and CRT tasks. Muscle activity was recorded from the biceps brachii muscle of each arm using electromyography to facilitate the fractionating of RT into premotor and motor components.ResultsALC children exhibited significantly slower premotor RTs during the CRT task. Motor RTs were also slower for the ALC group during both SRT and CRT tasks. ALC children exhibited greater response variability compared with control subjects; however, the magnitude of this variability was not greater than would be predicted, given their lengthened RTs. In contrast, response variability was greater for young children of both groups even after accounting for mean RT. Significant age‐related differences in premotor and motor RTs were also observed.ConclusionsAlcohol‐related increases in CRT were attributable to longer premotor and motor components, reflecting both reduced speed of information processing and peripheral delays in responding. These alterations likely are associated with alcohol‐related changes in the central and peripheral nervous systems that could impede or slow neuronal transmission.