A NEW FORM OF AMYLOID PROTEIN ASSOCIATED WITH CHRONIC-HEMODIALYSIS WAS IDENTIFIED AS BETA-2-MICROGLOBULIN
A NEW FORM OF AMYLOID PROTEIN ASSOCIATED WITH CHRONIC-HEMODIALYSIS WAS IDENTIFIED AS BETA-2-MICROGLOBULIN
复制标题
DOI：
10.1016/0006-291x(85)91948-5
复制
发表时间：
1985-01-01
影响因子：
3.1
通讯作者：
SCHMID, K
中科院分区：
文献类型：
--
作者：
GEJYO, F;YAMADA, T;SCHMID, K
从一名患有腕管综合征的慢性血液透析患者的淀粉样蛋白组织中分离出淀粉样纤维。在盐酸胍中增溶后，相当数量的蛋白质定位于均一的低分子量组分。该蛋白与β2-微球蛋白的相对分子质量为11,000，氨基酸组成和16个氨基端氨基酸相同：Ile-Gln-Arg-Thr-Pro-Lys-Ile-Gln-Val-Tyr-Ser-Arg-His-Pro-Ala-Glu-.显然，与慢性血液透析相关的淀粉样蛋白含有一种与β2-微球蛋白同源的新型淀粉样原纤维蛋白作为主要成分。
Amyloid fibrils were isolated from amyloid-laden tissue obtained from a chronic hemodialysis patient with carpal tunnel syndrome. After solubilization in guanidine HCl, a significant amount of the protein was located in a homogeneous low MW fraction. The protein was found to be identical to .beta.2-microglobulin, with regard to its MW of 11,000, amino acid composition and 16 amino-terminal amino acids: Ile-Gln-Arg-Thr-Pro-Lys-Ile-Gln-Val-Tyr-Ser-Arg-His-Pro-Ala-Glu-. Apparently the amyloid associated with chronic hemodialysis contains as a major component a new form of amyloid fibril protein that is homologous to .beta.2-microglobulin.